摘要
目的:系统分析和评价葛根芩连汤治疗2型糖尿病(Type 2 Diabetes Mellitus,T2DM)的降糖疗效。方法:以“葛根芩连汤”“糖尿病”“消渴”作为主要检索词,在万方、知网、维普三大中文数据库中进行自建库至2018年6月公开发表的相关文献的检索,疗程≥8周。采用改良的Jadad量表及Cochrane系统评价手册的发表偏倚评估对收集文献进行质量评价。设计表格,对纳入研究的文献进行数据提取。根据结局指标的单位、性质,选择统计模式,并采用RevMan 5.3软件对相关结局指标进行数据合并统计分析。结果:本研究共检索了351篇文章,符合研究纳入标准、干预措施及采用Jadad量表评分的有9篇。收集相关数据,并采用RevMan 5.3软件对收集的数据进行统计分析,观察组葛根芩连汤联合二甲双胍在改善糖尿病相关指标的有效率方面明显优于对照组单用二甲双胍;葛根芩连汤联合二甲双胍治疗与单用二甲双胍治疗,在降低2型糖尿病患者糖化血红蛋白(HbAlc)方面疗效相当,差异无统计学意义;葛根芩连汤联合二甲双胍治疗在降低2型糖尿病患者空腹血糖方面优于单用二甲双胍治疗;葛根芩连汤联合二甲双胍治疗在降低2型糖尿病患者餐后2小时血糖方面优于单用二甲双胍治疗。结论:葛根芩连汤具有显著降低血糖作用。
Objective:To systematically analyze and evaluate the hypoglycemic effect of the Gegen Qinlian decoction(葛根芩连汤)on type 2 diabetes mellitus.Methods:The Gegen Qinlian decoction,diabetes,thirst were selected as the main retrieval words,and related literaures with 8 weeks of treatment from construction of databases to publicly published in June 2018 were retrieved in three major Chinese databases,such as Wanfang Data,CNKI,VIP.The quality of the literatures was assessed by the publication bias assessment standard of the modified Jadad scale and the Cochrane system evaluation manual.The design form was used to extract data from the literaures included in the study.According to the unit and nature of the outcome indicators,the statistical model was selected,and the RevMan 5.3 software was used to analyze the relevant outcome indicators.Results:351 articles were retrieved in the databases in this study,and there were 9 articles met the inclusion criteria,intervention measures and Jadad scale scores.Relevant data was collected and analyzed in RevMan 5.3 software.The results show that the effects in the observation group(took the Gegen Qinlian decoction with metformin)were obviously better than those in the control group(took metformin only).The Gegen Qinlian decoction with metformin on type 2 diabetes mellitus showed similar influence in reducing the glycosylated hemoglobin compared with metformin only.The Gegen Qinlian decoction with metformin was better than metformin only in reducing the fasting plasma glucose and the 2 hours postprandial plasma glucose in patients with type 2 diabetes mellitus.Conclusion:The Gegen Qinlian decoction shows a significant effect on reducing blood sugar.
出处
《中医临床研究》
2020年第31期136-141,共6页
Clinical Journal Of Chinese Medicine
基金
福建省医疗“创双高”建设省级临床重点专科(中医类)建设项目,闽卫中医函(2017)881号。
关键词
葛根芩连汤
2型糖尿病
系统评价
The Gegen Qinlian decoction
Type 2 diabetes mellitus
Systematic evaluation