木丹颗粒联合依帕司他、甲钴胺在糖尿病痛性神经病变的疗效观察

Clinical observation on treating painful diabetic neuropathy with the Mudan granules plus epalrestat with mecobalamin

目的:探讨木丹颗粒联合依帕司他、甲钴胺在糖尿病痛性神经病变中的应用效果。方法:选取2015年10月-2019年10月我院内分泌科治疗的120例糖尿病痛性神经病变患者作为研究对象,随机分为两组,每组60例。对照组采用依帕司他、甲钴胺进行治疗,观察组则联合木丹颗粒治疗,疗程均为30天。对比两组治疗前、后双下肢腓总神经传导速率、疼痛数字评分法(Numerical Rating Scale,NRS)、中医证候积分、氧化应激指标水平。结果:治疗前两组各项观察指标比较,差异无统计学意义(P>0.05);治疗30天后,观察组双下肢腓总神经传导速率和中医证候积分均高于对照组,NRS评分低于对照组,差异有统计学意义(P<0.05);观察组超氧化歧化酶(Superoxide Dismutase,SOD)水平高于对照组,且超敏C反应蛋白(Hypersensitive C-reactive Protein,hs-CRP)水平低于对照组,差异有统计学意义(P<0.05)。结论:木丹颗粒联合依帕司他、甲钴胺治疗糖尿病痛性神经病变效果显著,能显著提升双下肢腓总神经传导速率,改善临床症状,降低疼痛程度和氧化应激反应,利于患者预后恢复,具有较高的临床应用价值。

Objective:To explore the effects of the Mudan granules(木丹颗粒)plus epalrestat with mecobalamin on painful diabetic neuropathy.Methods:120 cases were divided into two groups,60 cases in each group.The control group was treated with epalrestat and mecobalamin,and the observation group was treated with the Mudan granules more.Results:After 30 days of treatment,lower limbs peroneal nerve conduction velocity and TCM syndrome scores in the observation group were higher than those in the control group,and the NRS scores were lower compared with the control group(P<0.05).SOD level in the observation group was higher,and hs-CRP level in the observation group was lower than the control group,P<0.05.Conclusion:The Mudan granules plus epalrestat with mecobalamin are obviously effective on painful diabetic neuropathy,which can significantly increase lower limbs peroneal nerve conduction velocity,relieve clinical symptoms,and reduce the pain and oxidative stress response.It is beneficial to the prognosis recovery of the patients and has high clinical application value.