奥曲肽联合白蛋白对重症急性胰腺炎患者肠黏膜屏障功能的影响

Effect of octreotide combined with albumin on intestinal barrier function in patients with severe acute pancreatitis

目的分析奥曲肽联合白蛋白治疗重症急性胰腺炎患者的临床效果。方法选取2017年4月至2018年6月本院收治80例重症急性胰腺炎患者作为研究对象,采用随机数字表法分为观察组和对照组,每组40例。对照组患者采用常规治疗+奥曲肽,观察组采用常规治疗+奥曲肽+白蛋白。比较两组患者治疗后肠黏膜屏障功能[二胺氧化酶(DAO)、D-乳酸、内毒素]指标变化,同时比较临床相关指标改善情况。结果治疗前,两组患者DAO、D-乳酸、内毒素水平比较差异无统计学意义;治疗后,观察组患者DAO、D-乳酸、内毒素水平均低于对照组,差异有统计学意义(t=7.011、14.091、6.034,P均=0.000);观察组患者腹痛消失时间、退热时间、血淀粉酶恢复时间、住院时间均短于对照组,差异有统计学意义(t=2.952、4.314、3.380、3.932,P=0.004、0.000、0.001、0.000)。结论奥曲肽联合白蛋白治疗重症急性胰腺炎患者临床效果显著,可有效改善患者临床症状,缩短住院时间,促进肠黏膜屏障功能恢复。

Objective To analyze the clinical effect of octreotide combined with albumin in the treatment of patients with severe acute pancreatitis.Methods 80 patients with severe acute pancreatitis were treated in our hospital from April 2017 to June 2018,and the randomized digital method was divided into observation group and control group,with 40 cases in each group.Patients in the control group were treated with conventional treatment+octreotide,and the observation group was treated with routine treatment+octreotide+albumin.Compare the changes of index of intestinal mucosal barrier function[DAO,D lactic acid,endotoxin]after treatment in two groups,and compare the improvement of clinically relevant indexes.Results Before treatment,there was no significant difference in the levels of DAO,D-lactic acid and endotoxin between the two groups,but the levels of DAO,D-lactic acid and endotoxin in the observation group were significantly lower than those in the control group after treatment(t=7.011,14.091,6.034,P=0.000).The disappearance time of abdominal pain,the antipyretic time,the recovery time of serum amylase and the hospitalization time of the patients in the observation group were shorter than those in the control group,the difference was statistically significant(t=2.952,4.314,3.380,3.932,P=0.004,0.000,0.001,0.000).Conclusion Octreotide combined with albumin is effective in the treatment of severe acute pancreatitis,which can effectively improve the clinical symptoms,shorten the hospitalization time and promote the recovery of intestinal barrier function.