蒿甲醚治疗疟疾的应用及症状转归情况探究

Study on the application and symptom outcome of artemether treatment for malaria

目的探讨蒿甲醚治疗疟疾的应用及症状转归情况。方法选取2018年11月至2019年10月本院收治的60例疟疾患者作为研究对象,采用随机数字表法分为研究组和对照组,每组30例,对照组采用氯喹治疗,研究组采用蒿甲醚治疗,比较两组患者体温恢复正常时间、24 h体温正常率、临床治愈率、死亡率、复燃率及不良反应。结果研究组体温恢复正常时间优于对照组,差异有统计学意义(P<0.05);研究组患者临床治愈率、死亡率、复燃率明显优于对照组,差异有统计学意义(P<0.05);研究组无明显不良反应,对照组17例出现胃肠不适症状,12例出现头晕、头痛症状,8例出现皮肤瘙痒症状,3例出现耳鸣症状,7例出现心悸症状。结论蒿甲醚治疗疟疾效果显著,值得临床推广应用。

Objective To investigate the application of artemether in the treatment of malaria and the outcome of symptoms.Methods 60 cases of malaria patients admitted to our hospital from November 2018 to October 2019 were selected as the research objects.They were divided into study group and control group using random number table method,with 30 cases in each group.The control group was treated with chloroquine and the study group was treated with artemether treatment.The time to normal temperature,24 h normal temperature rate,clinical cure rate,mortality rate,reignition rate and adverse reactions were compared between the two groups.Results The normal temperature recovery time of the study group was better than that of the control group,and the difference was statistically significant(P<0.05).The clinical cure rate,death rate and recurrence rate in the study group were significantly better than those in the control group,and the difference was statistically significant(P<0.05).There were no obvious adverse reactions in the study group,in the control group,17 cases had gastrointestinal discomfort,12 cases had dizziness and headache,8 cases had pruritus,3 cases had tinnitus and 7 cases had palpitations.Conclusion Artemether is effective in treating malaria and is worthy of clinical application.