桂林市体检人群高同型半胱氨酸血症与血脂及体重指数关系分析

Analysis on the relationship between hyperhomocysteinemia and blood lipid and BMI in healthy people taking medical examination in Guilin

目的探讨桂林市健康体检人群高同型半胱氨酸血症(HHcy)的分布情况及与血总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和体质量指数(BMI)的相关性。方法回顾性选取2017年7月~2018年10月在联勤保障部队桂林康复疗养中心体检的健康体检者1768例,对其进行人口学特征及HHcy检出情况分析;并根据年龄和同型半胱氨酸(Hcy)水平分组比较,并通过单元和多元线性回归分析研究HHcy与血脂和BMI的关系。结果1768例体检者HHcy患病率15.2%,其中男性为23.1%,女性为6.0%,男性组明显高于女性组,差异有统计学意义(P<0.05);不同年龄分组比较,Hcy中位水平随着年龄的增长而升高,差异有统计学意义(P<0.05);HHcy组TC、HDL-C、LDL-C中位数分别与正常同型半胱氨酸(NHcy)组比较,差异有统计学意义(P<0.05)。回归分析显示,lnHcy与lnTG及lnBMI呈正相关(β=2.319、0.176,P<0.05),lnHcy与lnHDL-C呈负相关(β=-0.065,P=0.017),当Hcy为分组变量时,HHcy组相对于NHcy组具有较高水平的lnTC、lnLDL-C和lnBMI,差异有统计学意义(P<0.05)。结论HHcy是TC、TG、LDL-C及BMI水平升高、HDL-C水平降低的独立危险因素。

Objective To explore the distribution of hyperhomocysteinemia(HHcy)and its relationship with blood lipid(TC,TG,HDL-C,LDL-C)and body mass index(BMI)in healthy people taking medical examination in Guilin.Methods A total of 1768 healthy people who were examined at the Guilin Rehabilitation Center of the Joint Logistics Service Force from July 2017 to October 2018 were selected for analysis of their demographic characteristics and HHcy detection.The subjects were grouped and compared based on age and Hcy level.The relationship between HHcy,blood lipid and BMI was studied through unit and multiple linear regression analysis.Results The prevalence of HHcy was 15.2%among 1768 subjects examed,including 23.1%in males and 6.0%in females.The prevalence in the male group was significantly higher than that in the female group(P<0.05).The median level of Hcy increased with age(P<0.05).The median values of TC,HDL-C and LDL-C in HHcy group were statistically different from those in normal homocysteine(NHcy)group(P<0.05).Regression analysis showed that lnHcy was positively correlated with lnTG and lnBMI[lnTG(β=2.319,P=0.001),lnBMI(β=0.176,P=0.014)],and lnHcy was negatively correlated with lnHDL-C(β=-0.065,P=0.017).When Hcy was a grouping variable,HHcy group had higher levels of lnTC,lnLDL-C and lnBMI than NHcy group(P<0.05).Conclusion HHcy was an independent risk factor for increased levels of TC,TG LDL-C and BMI,and decreased HDL-C levels.