肠道菌群与冠心病发病相关机制及治疗

The related mechanism and treatment of gut microbiota and coronary heart disease

肠道菌群与心血管疾病显著相关。肠道菌群与冠心病发病相关机制的关键点在于肠道菌群失调及肠道菌群代谢物可导致冠状动脉粥样硬化。冠状动脉粥样硬化是冠心病的主要病理改变,肠道菌群在冠心病发生发展中具有重要的作用。肠道菌群依赖性代谢物氧化三甲胺可独立预测冠心病的不良预后。将肠道菌群作为冠心病新的治疗靶点已成为未来的研究重点。本文将综述肠道菌群与冠心病发病相关机制及治疗的最新研究进展,为进一步探索肠道菌群作为冠心病治疗靶点的潜力提供参考。

Recently,a significant association between gut microbiota and cardiovascular disease has been well recognized.The disorder of gut microbiota and metabolites of gut microbiota can lead to coronary atherosclerosis,which is the related key mechanism of gut microbiota and coronary heart disease.Coronary atherosclerosis is the main pathological change of coronary heart disease.The role of gut microbiota in the occurrence and development of coronary heart disease is important.And trimethylamine N-oxide,a gut bacteria-dependent metabolite,can independently predict the poor prognosis of coronary heart disease.In future,gut microbiota as a new therapeutic target for coronary heart disease is the focus of research.This paper reviews the latest research progress on the related mechanism and treatment of gut microbiota and coronary heart disease,so as to provide reference for further exploration of the potential of gut microbiota as a therapeutic target for coronary heart disease.