摘要
肾纤维化是各种病因引起的慢性肾脏病(chronic kidney disease,CKD)进展至终末期肾衰竭(endstage renal disease,ESRD)的主要病理改变,最终会导致肾脏组织结构破坏及肾功能完全丧失。研究发现,组蛋白去乙酰化酶(histone deacetylase,HDAC)介导的表观遗传学修饰与肾纤维化的发生发展密切有关。沉默信息调节因子2相关酶1(silent information regulator factor 2-related enzyme 1,SIRT1)属于Ⅲ类HDAC。研究表明,SIRT1在多种肾脏疾病中具有保护作用。本文就SIRT1在肾纤维化中的作用进行综述,旨在为肾纤维化的防治提供新的靶点和思路。
Renal fibrosis is the main pathological change caused by various causes of chronic kidney disease(CKD)progressing to end-stage renal disease(ESRD),which eventually leads to the destruction of kidney tissue structure and complete loss of kidney function.In recent years,it has been found that the histone deacetylase(HDAC)-mediated epigenetic modification is tightly associated with the occurrence and development of renal fibrosis.Silent information regulator factor 2-related enzyme 1(SIRT1)belongs to classⅢHDAC.New researches have shown that SIRT1 has protective effects in multiple kidney diseases.This article reviews the role of SIRT1 in renal fibrosis,hoping to provide new targets and ideas for the prevention and treatment of renal fibrosis.
作者
陈林林
刘云涛
吴娇
胡斌
CHEN Linlin;LIU Yuntao;WU Jiao;HU Bin(Medical College of China Three Gorges University,Yichang 443002,China;Department of Nephrology,Affiliated Ren He Hospital of China Three Gorges University,Yichang 443001,China)
出处
《生命的化学》
CAS
CSCD
2020年第11期1994-1999,共6页
Chemistry of Life
基金
湖北省卫生健康委员会联合基金项目(WJ2019H561)。
关键词
慢性肾脏病
肾纤维化
组蛋白去乙酰化酶
沉默信息调节因子2相关酶1
chronic kidney diseases
renal fibrosis
histone deacetylase
silent information regulator factor 2-related enzyme 1
