NIPPV联合纤维支气管镜肺泡灌洗术治疗COPD急性加重患者对其动脉血气指标的影响

Effects of NIPPV combined with bronchoalveolar lavage on arterial blood gas indexes in patients with acute exacerbation of COPD

目的探讨无创正压通气(NIPPV)联合纤维支气管镜肺泡灌洗术(BAL)治疗对慢性阻塞性肺急性加重(AECOPD)患者的动脉血气指标的影响。方法选取本院2018年9月至2019年8月收治的AECOPD患者303例,按随机编号法分为对照组151例以及联用组152例。对照组仅给予NIPPV治疗,联用组给予NIPPV联合BAL治疗。观察比较两组患者治疗前后动脉血气各项指标的变化。结果治疗后,两组患者的酸碱度(pH)、二氧化碳分压(PaCO2)、血氧分压(PaO2)和动脉血氧饱和度(SaO2)分别升高、降低、升高、升高,其中观察组的各项指标均显著优于对照组(P<0.05)。结论采取NIPPV联合BAL治疗的方式可有效改善AECOPD患者的动脉血气各项指标,值得临床推荐。

Objective To explore effects of noninvasive positive pressure ventilation(NIPPV)combined with bronchoalveolar lavage(BAL)on arterial blood gas indexes in patients with acute exacerbation of chronic obstructive pulmonary(AECOPD).Methods A total of 303 AECOPD patients admitted to the hospital from September 2018 to August 2019 were enrolled.They were divided into a control group(151 cases)and a combination group(152 cases)by the random numbering method.The control group was treated with NIPPV,while the combination group was treated with NIPPV and BAL.Before and after treatment,the changes of arterial blood gas indexes were observed and compared between the two groups.Results After treatment,the potential of hydrogen(pH)was increased,the partial pressure of carbon dioxide(PaCO2)was decreased,the partial pressure of blood oxygen(PaO2)and arterial oxygen saturation(SaO2)were increased in both groups.All the indexes of the observation group were significantly better than those of the control group(P<0.05).Conclusion NIPPV combined with BAL can effectively improve arterial blood gas indexes of AECOPD patients.