^18F-FDG不同分装方式下操作人员受照剂量的比较

Comparison of extremity dose for different dispensing methods of fluorine-18-fluorodeoxyglucose

目的比较临床常用的手工分装、全自动分装和PET药物分装注射系统三种方式分装氟代脱氧葡萄糖(fluorine-18-fluorodeoxyglucose,^18F-FDG)的分装时间、分装准确性和分装人员手部及眼部受照剂量。方法分装的目标活度为296 MBq,在分装人员双手食指根部、双手腕外侧以及铅防护眼镜固定位置佩戴热释光剂量计,同一分装人员分别用三种方式进行30例次^18F-FDG分装,每次分装活度在296 MBq±10%以内为达标,记录每例次的分装次数、每次分装活度和分装时间。结果完成30例次分装,三种分装方式的分装次数分别为43、47和30次,首次分装成功率分别为76.67%、73.33%和100%,平均每次目标分装的次数分别为1.43、1.56和1例次,平均每例次分装时间分别为(39.15±32.80)s、(203.60±203.11)s和(82.29±26.11)s。计算三种分装方式所测个人剂量当量,手部剂量当量最高的位置为左右双手食指底部,左手和右手手工分装分别为(1231.48±29.40)μSv/GBq和(1281.24±121.00)μSv/GBq、全自动分装分别(862.49±30.50)μSv/GBq和(678.64±51.68)μSv/GBq,PET药物分装注射系统分别为(4.50±2.25)μSv/GBq和(7.88±1.13)μSv/GBq。三种分装方式左右眼晶体剂量当量分别为3.39μSv/GBq和4.5μSv/GBq、1.69μSv/GBq和2.5μSv/GBq、1.69μSv/GBq和0。按国家标准年剂量限值估算三种分装方式下分装人员年度分装例次分别为1319、1964和214364例次。结论PET药物分装注射系统的分装成功率、准确性和稳定性最高,辐射防护最好,可减少分装人员配置。

Objective Three commonly used clinical fluorodeoxyglucose(fluorine-18-fluorodeoxyglucose,^18F-FDG)dispensing methods including manual dispensing,automatic dispensing and PET drug dispensing injection system were compared in dispensing time,dispensing accuracy and exposure dose of hand and eyes of nuclear medicine workers.Methods Thermoluminescence dosimeters were fixed at the index finger bases of both hands,the outside of the wrists of both hands and lead protective glasses of dispensing workers,respectively.^18F-FDG was dispensed 30 times by the same dispensing worker using three different ways,such as manual dispensing,automatic dispensing,and PET drug dispensing injection system,respectively.Within±10%of the target activity of 296 MBq each dispensing was qualified,and the number of dispensing,the activity of each dispensing,and the dispensing time of each experiment were recorded.Results The number of dispensing times of manual dispensing,automatic dispensing and PET drug dispensing injection system were 43,47 and 30,respectively.The success rate of the first dispensing was 76.67%,73.33%and 100%,respectively.The average dispensing times and time of each case were 1.43 and(39.15±32.80)s,1.56 and(203.60±203.11)s,1 and(82.29±26.11)s,respectively.The individual dose equivalent measured by the three methods was calculated.The highest dose equivalent of the hand was at the base of index finger of left and right hand,with(1231.48±29.40)μSv/GBq and(1281.24±121.00)μSv/GBq by manual dispensing,(862.49±30.50)μSv/GBq and(678.64±51.68)μSv/GBq by automatic dispensing,and(4.50±2.25)μSv/GBq and(7.88±1.13)μSv/GBq by the PET drug injection system,respectively.The dose equivalents of the left and right ocular lens of the three different loading methods are 3.39μSv/GBq and 4.5μSv/GBq,1.69μSv/GBq and 2.5μSv/GBq,1.69μSv/GBq and 0,respectively.Therefore,the most number of dispensing times of dispensing worker was estimated to be 1319,1964 and 214364 times/year under the three dispensing methods according to annual dose equivalent limit of national standards,respectively.Conclusion PET drug dispensing injection system not only has the highest dispensing success rate,accuracy,and stability,but also the best radiation protection.The use of PET drug dispensing injection system can reduce the staffing configuration.