摘要
of main observ ation and conclu sion Site-selective borylation of simple arenes was realized in one pot via an electrophilic thianthrenation/Pd-catalyzed borylation sequence.The key to achieve this operatically simple process is the use of Pd catalysis,which could tolerate the solvent and acidic conditions used in the thianthrenation step.This protocol features mild conditions,broad functional group tolerance,and simple manipulations,and is suitable for late-stage functionalization of a wide range of pharmaceuticals and complex bioactive molecules.
基金
We gratefully acknowledge Shanghai Institute of Organic Chemistry,State Key Laboratory of Organometallic Chemistry,the National Natural Science Foundation of China(No.21821002)for financial support.