摘要
of main observation and conclusion We herein report the first example of iridium-catalyzed enantioselective C(sp^3)-H borylation of cyclobutanes using benzoxazoline as the directing group.The combination of a chiral bidentate boryl ligand and an iridium precursor has found to effectively catalyze C(sp)-H borylation to afford a variety of cyclobutylboronates with good to excellent enantioselectivities.We also demonstrate the synthetic utility of the current method by converting the stereogenic C—B bond to other functionalities.
基金
We thank the National Natural Science Foundation of China(21573262,21776260,21873261,and 91956116)
the Natural Science Foundation of Jiangsu Province(BK20170422)for thegenerous support.
