摘要
of main observation and conclusion A palladium-catalyzed asymmetric[4+3]cycloaddition of trimethylenemethanes and indoline-derived aza-dienes has been developed.The potential[3+2]side pathway was completely suppressed in the process.This protocol provides an efficient access to azepino[2,3-b]indoles bearing two vicinal stereocenters in generally excellent diastereo-and enantioselectivities(up to>20:1 dr,99% ee).
基金
This work is supported by the National Natural Science Foundation of China(Nos.21772038,21971062,and 21901072)
Shanghai Sailing Program(No.18YF140560).
