Nickel-Catalyzed Cross-Coupling of Aryl Pivalates with Cyclobutanols Involving C-O and C-C Bond Cleavage

of main observation and conclusion An efficient nickel-catalyzed cross-coupling of aryl pivalates with cyclobutanols is described.The use of Ni(cod)2/PCy3/base as the catalytic system enables the cleavage of inert C—0 bond and C—C bond under mild conditions,thus providing a facile access to y-arylated ketones in generally good to excellent yields.This transformation is also characterized by wide substrate scope and functional group compatibility,for example,methoxy,γ-dimethylamino,keto,ester,fluoro and TMS groups are well-tolerated during the reaction process.