逍遥散联合重复经颅磁刺激治疗肝郁脾虚型抑郁症疗效及对患者血清FGF-22、BDNF水平的影响

Efficacy of Xiaoyao powder combined with repeated transcranial magnetic stimulation in the treatment of depression of liver depression and spleen deficiency and its effect on serum FGF-22 and BDNF levels

目的:研究肝郁脾虚型抑郁症使用逍遥散联合重复经颅磁刺激治疗效果及其对患者血清成纤维细胞生长因子22(FGF-22)、血清脑源性神经营养因子(BDNF)水平的影响。方法:选择肝郁脾虚型抑郁症患者94例,随机对照组和观察组各47例,对照组使用重复经颅磁刺激,观察组在对照组基础上使用逍遥散,均实施为期8周治疗。观察两组患者治疗后临床疗效,统计治疗前后血清白介素-4(IL-4)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、BDNF、FGF-22水平,对比治疗前后汉密尔顿抑郁量表(HAMD)、负性认知加工偏向问卷(NCPBQ)、匹兹堡睡眠质量指数问卷(PSQI)评分。结果:观察组治疗后临床有效率为85.11%,高于对照组65.96%(P<0.05);观察组治疗后IL-4、IL-6、TNF-α水平改善优于对照组(P<0.05);观察组治疗BDNF、FGF-22水平高于对照组(P<0.05);观察组治疗后HAMD量表、NCPBQ问卷、PSQI问卷评分均低于对照组(P<0.05)。结论:逍遥散联合重复经颅磁刺激能有效改善肝郁脾虚型抑郁症患者临床症状和体征,通过调节患者血清中炎症指标、FGF-22、BDNF水平,不仅能改善患者精神状态,还可在一定程度上调节其负性认知。

Objective:To study the therapeutic effect of Xiaoyao powder combined with repeated transcranial magnetic stimulation and its effect on serum FGF-22 and BDNF levels in depression of liver depression and spleen deficiency.Methods:94 patients with depression of liver depression and spleen deficiency were randomly divided into control group(n=47)and observation group(n=47).The control group was treated with repetitive transcranial magnetic stimulation and the observation group was treated with Xiaoyao powder on the basis of the control group.All patients were treated for 8 weeks.The clinical efficacy of the two groups after treatment was observed,and the levels of serum interleukin-4(IL-4),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),serum brain-derived neurotrophic factor(BDNF)and fibroblast growth factor 22(FGF-22)were counted before and after treatment.The scores of Hamilton Depression Scale(HAMD),Negative cognitive processing bias questionnaire(NCPBQ)and Pittsburgh Sleep Quality Index Questionnaire(PSQI)were compared before and after treatment.Results:The clinical effective rate of the observation group after treatment was 85.11%,which was higher than that of the control group(65.96%).The levels of IL-4,IL-6 and TNF-αin the observation group were better than those in the control group(P<0.05).The levels of BDNF and FGF-22 in the observation group were higher than those in the control group(P<0.05).The scores of HAMD scale,NCPBQ questionnaire and PSQI questionnaire in the observation group were lower than those in the control group(P<0.05).Conclusion:Xiaoyao powder combined with repetitive transcranial magnetic stimulation can effectively improve the clinical symptoms and signs of patients with depression of liver depression and spleen deficiency.By regulating the levels of inflammatory indexes,FGF-22 and BDNF in serum,it can not only improve the mental state of patients,but also regulate their negative cognition to some extent.