防己黄芪汤加减对肾病综合征患儿免疫状态的调节作用及疗效分析

Analysis of Regulation Effect and Clinical Efficacy of Fangji Huangqi Decoction's Dose on Immune Status in Children with Nephrotic Syndrome

目的:探讨防己黄芪汤加减对肾病综合征患儿免疫状态的调节作用及临床疗效。方法:回顾性分析2018年1月—2019年12月本院收治的80例肾病综合征患儿临床资料,根据治疗方式不同分组,将采用醋酸泼尼松片治疗的40例患儿归为对照组,将采用醋酸泼尼松片+防己黄芪汤加减治疗的40例患儿归为观察组,对比两组T淋巴细胞亚群、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、水肿消退与尿蛋白转阴时间及复发率。结果:治疗前,两组CD3+、CD4+、CD8+及CD4+/CD8+比较,差异无统计学意义(P>0.05)。治疗后,两组CD4+、CD4+/CD8+及CD3+较治疗前明显升高,且观察组高于对照组;两组CD8+较治疗前明显降低,且观察组低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组IgA、IgG水平比较,差异无统计学意义(P>0.05);治疗后,两组IgA、IgG水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组水肿消退时间及尿蛋白转阴时间均短于对照组,差异有统计学意义(P<0.05)。观察组复发率低于对照组,差异有统计学意义(P<0.05)。结论:防己黄芪汤加减治疗肾病综合征可提高T淋巴细胞亚群活性,改善免疫功能,缩短水肿消退时间及尿蛋白转阴时间,有效降低复发率。

Objective:To explore the regulatory effect and clinical efficacy of Fangji Huangqi decoction's dose on the immune status of children with nephrotic syndrome.Methods:The clinical data of 80 children with nephrotic syndrome received in our hospital from January 2018 to December 2019 were retrospectively analyzed.According to different treatment methods,the clinical data of 40 children who were treated with prednisone were classified as a control group,The clinical data of 40 children who were treated with Qiangsong+Fangji Huangqi decoction were divided into the observation group,and compared the T lymphocyte subsets,immunoglobulin A(IgA),immunoglobulin G(IgG),edema subsided,urine protein turning negative time and recurrence rate between the two groups.Results:After treatment,the observation group CD3+,CD4+and CD4+/CD8+were higher than the control group,CD8+was lower than the control group,the difference was statistically significant(P<0.05);after treatment,the levels of IgA and IgG in the two groups were higher than before treatment.And the above-mentioned index level of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05);the edema resolution time and urine protein negative time of the observation group were shorter than the control group,the difference was statistically significant(P<0.05).The recurrence rate of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:Modification of Fangjihuangqi Decoction can increase the liveness of T lymphocyte subsets in children with nephrotic syndrome,improve immune function,shorten the time of edema resolution and urine protein negative and reduce the recurrence rate effectively.