补肾养肝熄风汤治疗帕金森伴轻度认知功能障碍患者后脑电图变化分析

Analysis of Electroencephalogram Changes in Patients with Mild Cognitive Impairment in Parkinson's Disease after Treatment with Bushen Yanggan Xifeng Decoction

目的:探讨补肾养肝熄风汤治疗帕金森伴轻度认知功能障碍(PD-MCI)患者后脑电图变化。方法:以本院2017年11月至2019年11月收治的80例PD-MCI患者为研究对象,利用计算机产生随机数字后采用简单随机分组法分为观察组(40例)、对照组(40例)。对照组给予常规药物治疗,观察组在此基础上加服养肝熄风汤。治疗3个月后,评价两组疗效和认知功能指标,包括蒙特利尔认知功能评分(MOCA)、简易精神状态评分(MMSE)及脑电图指标(α、β、θ、δ频段相对功率谱)变化。结果:观察组总有效率为90.00%,优于对照组的77.50%,有显统计学意义(P<0.05);治疗后观察组和对照组的MOCA、MMSE均显著升高(P<0.05),观察组的升高幅度明显高于对照组(P<0.05);治疗后,α和β频段相对功率谱平均值显著降低(P<0.05),观察组θ和δ频段相对功率谱平均值显著升高(P<0.05)。结论:补肾养肝熄风汤能提高PD-MCI的疗效,改善患者的认知功能和脑神经功能。

Objective:To explore the treatment of Parkinson's disease with mild cognitive impairment by Bushen Yanggan Xifeng decoction Changes of electroencephalogram after PD-MCI.Methods:80 cases of PD-MCI patients in our hospital from November 2017 to November 2019 were selected as the research objects.After random numbers were generated by computer,they were divided into observation group(40 cases)and control group(40 cases).The control group was given conventional drug treatment,and the observation group was given Yanggan Xifeng Decoction on this basis.After 3 months of treatment,the curative effect and cognitive function indexes of the two groups were evaluated,including Montreal cognitive function score(MOCA),mini mental state score(MMSE)and EEG index(α,β,θ,δband relative power spectrum).Results:The total effective rate of the observation group was 90.00%,which was better than 77.50%of the control group,with statistical significance(P<0.05);after treatment,MOCA and MMSE of the observation group and the control group were significantly increased(P<0.05),and the increase amplitude of the observation group was significantly higher than that of the control group(P<0.05);after treatment,the average value of relative power spectrum ofαandβbands was significantly decreased(P<0.05),and the relative power ofθandδbands in the observation group was significantly lower than that in the control group The mean value of spectrum increased significantly(P<0.05).Conclusion:Bushen Yanggan Xifeng decoction can improve the curative effect of PD-MCI,improve the cognitive function and brain nerve function of patients.