OSAHS合并肥胖低通气综合征患者的临床特征分析

Study on the clinical characteristics of obstructive sleep apnea-hypopnea syndrome combined with obesity hypopnea syndrome

目的:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并肥胖低通气综合征(OHS)患者的临床特征。方法:选取经整夜多导睡眠监测(PSG)确诊为OSAHS的患者100例,分为单纯OSAHS组43例和OSAHS合并OHS组57例,回顾性分析两组患者的临床资料特征。结果:OSAHS合并OHS组患者的颈围、腰围、动脉血PaCO2、快速眼球运动(REM)期呼吸暂停次数、整夜平均心率、SpO2低于90%的时间显著高于单纯OSAHS组(t=3.723、5.127,Z=7.893、2.411、2.019、2.203,均P<0.05),动脉血pH值和PaO2、肺功能FVC和FEV1、REM睡眠持续时间、N3期持续时间显著低于单纯OSAHS组(Z=3.367、3.025、3.306、3.019、2.085,均P<0.05)。结论:OSAHS合并OHS的动脉血气分析、肺功能和PSG结果等临床特征与单纯OSAHS存在明显差异。

Objective:To investigate the clinical characteristics of patients with obstructive sleep apnea-hypopnea syndrome(OSAHS)and obese hypopnea syndrome(OHS).Methods:The study selected 100 cases of obstructive sleep apnea-hypopnea syndrome diagnosed by overnight polysomnography(PSG).The cases were divided into OSAHS group(n=43)and OSAHS combined OHS group(n=57).The clinical data of the two groups were retrospectively analyzed.Results:The neck circumference,waist circumference,arterial blood PaCO2,number of apnea in REM phase,overnight average heart rate and time of SpO2 lower than 90%of patients with OSAHS and OHS were significantly lower than those in OSAHS group(t=3.723,5.127,Z=7.893,2.411,2.019,2.203,all P<0.05).Arterial blood pH,PaO2,lung function FVC and FEV1,duration of REM phase,duration of N3 phase were significantly lower than those in OSAHS group(Z=3.367,3.025,3.306,3.019,2.085,all P<0.05).Conclusion:Patients with OSAHS combined OHS have significant differences in clinical characteristics such as arterial blood gas analysis,lung function and PSG results from patients with OSAHS alone.