摘要
Objective:To observe the anti-hypertensive effect of time acupuncture on primary hypertension so as to provide the therapeutic regimen for the treatment of primary hypertension.Methods:A total of 120 patients with primary hypertension were randomized into a western medication group and an acupuncture-medication group,60 cases in each one.In the western medication group,levoamlodipine maleate tablets were prescribed for oral administration.In the acupuncture-medication group,on the base of the treatment as the western medication group,time acupuncture was combined in the period of a day from 7:00 a.m.to 9:00 a.m.The duration of treatment was 4 weeks in the two groups.Before and after treatment,blood pressure,serum endothelin(ET)and nitrious oxide(NO)were measured successively and the clinical therapeutic effect was evaluated.Results:(1)Blood pressure:the systolic and diastolic pressure after treatment were all lower than that before treatment in the two groups,indicating statistical differences(all P<0.05),After treatment,the systolic and diastolic pressure in the acupuncture-medication group were lower than that of the western medication group,indicating significant differences(both P<0.05).(2)ET and NO:after treatment,ET in the acupuncture-medication group was lower than the western medication group and NO was higher than the western medication group,indicating statistical differences(both P<0.05).(3)Clinical therapeutic effect:the total effective effect of anti-hypertension was 89%in the acupuncture-medication group,higher than 63%in the western medication group,indicating statistical difference(P<0.05).Conclusion:The combined treatment of western medication and time acupuncture(7:00 am to 9:00 am)achieves better effect on primary hypertension as compared with simple western medication and its anti-hypertensive effect is probably related to the decrease of ET and the increase of NO.
作者
王艳君
赵鑫
兰向东
许水清
张丽华
Yan-jun WANG;Xin ZHAO;Xiang-dong LAN;Shui-qing XU;Li-hua ZHANG(Affiliated Hospital of Hebei University of Traditional Chinese Medicine,Shijiazhuang 050011,China;Heibei Provincial Chinese Medicine Hospital,Shijiazhuang 050011,China;Cangzhou Integrated Traditional Chinese and Western Medicine Hospital,Cangzhou 061000,Hebei Province,China)
基金
supported by National key R&D Program:No.2018YFC1707803
Subject of Hebei Provincial Department of Finance:No.361025
Project of Hebei Provincial Administration of Traditional Chinese Medicine:No.2017054。