肿瘤标志物在肺癌诊断及预后预测中的临床应用价值分析

Value analysis of tumor markers on diagnosis and prognosis prediction of lung cancer

目的浅析肿瘤标志物检测对肺癌疾病诊断与预后评估的价值。方法纳入本单位2014年01月至2016年12月间罹患肺癌者70例作肺癌组,并纳同期入本院接受健康体检的健康者30例作健康组;肺癌组依照不同疾病类型又细分为小细胞组(22例)、鳞癌组(25例)与腺癌组(23例),依照肿瘤标志物检测阴阳性分布不同细分为阴性组(26例)与阳性组(44例),进行系列的统计学比较,分析肿瘤标志物检测对肺癌疾病诊断与预后评估的价值。结果肺癌组五项肿瘤标志物初始浓度检测值均高于健康组,差异有统计学意义(P<0.05);腺癌组CA125、CEA阳性检出率超85.00%,鳞癌组CYFAR21-1阳性检出率88.00%,且小细胞组、鳞癌组与腺癌组五项肿瘤标志物阳性检出率均高于健康组,差异有统计学意义(P<0.05);阴性组3年期死亡率(30.77%)低于阳性组(70.45%),差异有统计学意义(P<0.05)。结论肿瘤标志物可作为肺癌疾病诊断与预后评估的有效工具。

Objective To analyze the value of tumor markers on diagnosis and prognosis prediction of lung cancer.Methods 70 lung cancer patients treated from January 2014 to December 2016 in our unit were chosen as lung cancer group;over the same time period,30 healthy checkups were chosen as healthy group.According to different disease types,lung cancer group was sub-classified as small cell group(22 cases),squamous carcinoma group(25 cases)and adenocarcinoma group(23 cases).According to tumor marker results,patients were divided into negative group(26 cases)and positive group(44 cases).The values of tumor markers on diagnosis and prognosis prediction were discussed.Results The initial concentrations of five tumor markers in lung cancer group were significantly higher than healthy group(P<0.05);the positive detection rate of CA125(carbohydrate antigen 125)and CEA(carcino-embryonic antigen)in adenocarcinoma group was larger than 85.00%;the positive detection rate of CYFAR21-1(cytokerantin-19-fragment antigen21-1)in squamous carcinoma group was 88.00%.The positive detection rate of five tumor markers in small cell group,squamous carcinoma group and adenocarcinoma group was significantly higher than healthy group(P<0.05);three-year death rate in negative group(30.77%)was significantly lower than positive group(70.45%)(P<0.05).Conclusion The tumor markers are considered as the effective tools for diagnosis and prognosis prediction of lung cancer.