重复经颅磁刺激联合氯氮平治疗单纯型精神分裂症阴性症状的疗效

Efficacy of repetitive transcranial magnetic stimulation combined with clozapine in the negative symptoms of simple schizophrenia

目的:探讨重复经颅磁刺激联合氯氮平治疗单纯型精神分裂症阴性症状的临床效果。方法:选取2017年1月至2019年12月期间茂名市慢性病防治中心收治的60例复发单纯型精神分裂症患者,所有患者药物洗脱后入组,采用随机数字表法分为对照组和研究组,每组30例。对照组口服氯氮平治疗,研究组患者在口服氯氮平的基础上结合重复经颅磁刺激治疗。治疗8周后,采用阴性症状评定量表(SANS)、社会功能评估量表(SFRS)评定治疗效果。结果:治疗后,两组患者SANS评分明显低于治疗前,且研究组降低更明显(P<0.05)。研究组患者SFRS评分明显低于对照组(P<0.05);研究组患者的临床治疗有效率为93.3%(28/30例),明显高于对照组70.0%(21/30例),差异具有统计学意义(P<0.05)。结论:重复经颅磁刺激联合氯氮平治疗单纯型精神分裂症阴性症状患者,可以有效缓解患者的临床症状,改善患者社会功能。

Objective:To explore the efficacy of repetitive transcranial magnetic stimulation(rTMS)combined with clozapine in the negative symptoms of simple schizophrenia.Methods:Sixty patients with recurrent simple schizophrenia in Maoming Center for Chronic Disease Control from January 2017 to December 2019,were randomly divided into control group and study group after drug-elution,30 cases in each group.The patients were treated with clozapine in the control group,rTMS combined with clozapine in the study group.After 8 weeks of treatment,the effects were evaluated by the scale for assessment of negative symptom(SANS)and social function rating scale(SFRS).Results:Compared with before the treatment,SANS scores were significantly lower after the treatment in the two groups,more obvious in the study group(P<0.05).The SFRS scores were significantly lower in the study group than those in the control group(P<0.05).The effective rate was significantly higher in the study group than that in the control group(93.3%vs.70.0%,P<0.05).Conclusion:rTMS combined with clozapine can effectively relieve the clinical symptoms and improve the social function in patients with simple schizophrenia.