基于脂质组学的子宫内膜异位症生物标志物研究进展

Research progress on biomarkers for endometriosis based on lipidomics

子宫内膜异位症的发病机制不明,缺乏有效的生物标志物,疾病的延误诊断非常突出。脂质组学技术为子宫内膜异位症的诊断和预测提供了新的途径。外周血、子宫内膜液、腹腔液和卵泡液的鞘磷脂、磷脂酰胆碱和磷脂酰丝氨酸等对子宫内膜异位症及疾病分型具有良好的诊断价值;在位子宫内膜的磷脂酰胆碱、磷脂酰丝氨酸联合磷脂酸有望成为早期子宫内膜异位症的生物标志物;外周血的脂代谢数据对预测子宫内膜异位症相关不孕也有重要价值。脂质组学技术的发展将进一步推进子宫内膜异位症相关发病机制、疾病预测、诊断和治疗等方面的研究进展。

The pathogenesis of endometriosis is not well understood at the moment,and the lack of effective biomarkers often leads to delayed diagnosis of the disease.Lipidomics provides a new approach for the diagnosis and prediction of endometriosis.Sphingomyelin,phosphatidylcholine and phosphatidylserine in peripheral blood,endometrial fluid,peritoneal fluid and follicular fluid have good diagnostic value for endometriosis and disease classification;the lipid metabolites in the eutopic endometrium tissue are expected to be biomarkers of early endometriosis;and the lipid metabolites in peripheral blood are also of great value for predicting endometriosis-related infertility.The development of lipidomics technique will further advance the progress on the pathogenesis,prediction,diagnosis and treatment of endometriosis.