不同类型免洗消毒液的长效抗菌和护肤效果分析

Analysis in efficiency of long-term antibacterial and skin care functions in different types of washing-free disinfectants

目的比较不同含醇复合配方(复配)体系免洗消毒液的长效抗菌效果。方法选取不同复配体系的免洗消毒液A、B、C、D、E、F,分别按其最优用量0.5~5.0 mL进行手消毒现场试验,观察消毒作用后手部皮肤菌落增长随时间的变化,并比较不同类型免洗消毒液在手部消毒1、2、3、4、5、6 h后的皮肤保湿效果。结果乙醇、增效剂、抗菌成膜剂、护肤剂复配的免洗消毒液在作用4 h后仍能使皮肤保持较低的菌落数,平均杀灭对数值仍可达到≥1的要求,与苄索氯铵或葡萄糖酸洗必泰活性消毒剂复配后的抑菌和保湿效果可以延长至6 h以上。结论乙醇、苄索氯铵、葡萄糖酸洗必泰、增效剂、抗菌成膜剂和护肤剂复配的免洗消毒剂具备长效抗菌和保湿护肤效果,效果可持续6 h以上。

Objective To compare the long-term antibacterial function of washing-free disinfectants with different types of alcohol-containing compound formula system.Methods Washing-free disinfectants with different types of alcohol-containing compound formula system were selected(A,B,C,D,E and F).According to the optimal dosage of 0.5 to 5.0 mL in each type,the field tests of hand disinfection were carried out.Change of bacterial colony growth of hand skin with extension of time after disinfection was observed,and the skin moisturizing effect of washing-free disinfectants with different types of compound formula system were compared at 1,2,3,4,5 and 6 h after hand disinfection.Results Washing-free disinfectants with components of ethanol,synergist,antibacterial film-forming agent and skin care agent were able to keep low colony forming units at 4 hours after hand disinfection,and its average killing log value could reach the requirement of≥1.The antibacterial and skin moisturizing functions when these washing-free disinfectants mentioned above prepared with benzalkonium chloride or chlorhexidine gluconate active disinfectant could last for more than 6 hours.Conclusion The disinfectantscomposed of ethanol,benzalkonium chloride,chlorhexidine gluconate,synergist,antibacterial film-forming agent and skin care agent have long-term antibacterial and skin moisturizing functions,which can last for more than 6 hours.