左乙拉西坦对癫痫患儿智力发育的影响

Effects of levetiracetam on the intellectual development of children with epilepsy

目的探讨左乙拉西坦对癫痫患儿智力发育的疗效及影响。方法将85例癫痫患儿随机分为对照组(n=42)和研究组(n=43)。对照组给予丙戊酸钠治疗,研究组给予左乙拉西坦治疗,2组均治疗6个月。比较2组智力发育水平变化、治疗总有效率、不良反应发生率以及炎症水平变化。结果治疗后,研究组智力发育水平高于对照组,差异有统计学意义(P<0.01);研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率与对照组比较,差异无统计学意义(P>0.05);研究组炎症水平低于对照组,差异有统计学意义(P<0.01)。结论左乙拉西坦治疗癫痫患儿效果更佳,可有效改善患儿智力发育水平、炎症水平,且安全性高。

Objective To investigate the effect of levetiracetam on the intelligence development of children with epilepsy and its influence.Methods Eighty-five children with epilepsy were randomly divided into control group(n=42)and study group(n=43).The control group was treated with sodium valproate,and the study group was treated with levetiracetam,both groups were treated for 6 months.The changes of intelligence development levels,total effective rate of treatment,incidence of adverse reactions and inflammatory levels were compared between the two groups.Results After treatment,the intelligence development level of the study group was significantly higher than that of the control group(P<0.01);the total effective rate of the treatment group was significantly higher than that of the control group(P<0.05);there was no statistically significant difference in the incidence of adverse reactions between the study group and the control group(P>0.05);the inflammation level of the study with high safety group was significantly lower than that of the control group(P<0.01).Conclusion Levetiracetam with nigh safety is more effective in the treatment of children with epilepsy,and can effectively improve the level of intellectual development and inflammation of children.