Ki-67表达对大肠癌预后及临床病理特征影响的Meta分析

A Meta-analysis of the influence of Ki-67 expression on the prognosis and clinicopathological characteristics of colorectal cancer

目的通过Meta分析探讨Ki-67表达与大肠癌预后及临床病理特征的相关性。方法检索PubMed、Embase、Web of science、中国知网数据库(CNKI)、维普数据库(VIP)及万方数据库等数据库自建立之日起至2020年4月30日的相关文献。文献质量评价采用Newcastle-Ottawa Scale(NOS),Meta分析应用Stata SE 15.1软件。结果共纳入43篇文献、10223例样本被纳入Meta分析。Ki-67的高表达与大肠癌(Colorectal cancer,CRC)患者的总生存期[HR=1.29,95%CI(1.07,1.55),P=0.006]和无病生存期[HR=1.59,95%CI(1.18,2.14),P=0.003]显著相关且与CRC的TNM分期[OR=2.70,95%CI(1.90,3.83),P=0.000]、淋巴结转移[OR=1.81,95%CI(1.23,2.66),P=0.003]、远处转移[OR=2.04,95%CI(1.17,3.58),P=0.013]以及病理分化程度[OR=1.72,95%CI(1.16,2.55),P=0.007]存在显著相关性。结论Ki-67高表达的CRC患者具有更差的总生存期和无病生存期,说明Ki-67可能是CRC一种潜在预后标志物并有可能成为CRC新的治疗靶点。

Objective To investigate the correlation between Ki-67 expression and prognosis and clinicopathological features of colorectal cancer.Methods A total of 43 articles were retrieved from PubMed,EMBASE,Web of Science,CNKI,CQVIP and Wanfang database.Newcastle Ottawa scale(NOS)and Stata SE 15.1 software were used for Meta-analysis.Results Ki-67 overexpression was associated with overall survival[HR=1.29,95%CI(1.07,1.55),P=0.006]and disease-free survival[HR=1.59,95%CI(1.18,2.14),P=0.003].There was significant correlation between TNM stage of CRC[OR=2.70,95%CI(1.90,3.83),P=0.000],lymph node metastasis[OR=1.81,95%CI(1.23,2.66),P=0.003],distant metastasis[OR=2.04,95%CI(1.17,3.58),P=0.013]and pathological differentiation[OR=1.72,95%CI(1.16,2.55),P=0.007].Conclusion CRC patients with high expression of Ki-67 have worse overall survival and disease-free survival,indicating that Ki-67 may be a potential prognostic marker for CRC and may become a new therapeutic target for CRC.