弹性成像技术联合甲状腺激素对甲状腺结节的诊断价值

Diagnostic value of elastography combined with thyroid hormone in thyroid nodules

目的:探讨弹性成像技术联合甲状腺激素在甲状腺结节患者中的诊断效果。方法:选择2018年3月至2019年6月疑似甲状腺结节患者88例为观察组,所有患者经穿刺和经甲状腺切除手术组织检查确诊。确诊前患者均完成弹性成像技术测定;采用全自动化学发光法测定患者甲状腺激素(thyroid hormone,TSH)水平。选择同期健康体检者57例为对照组。绘制ROC曲线,分析弹性成像技术联合TSH在甲状腺结节患者中的诊断敏感性、特异性。结果:疑似甲状腺结节患者88例中均经穿刺和手术组织检查确诊,其中良性结节51例(57.95%),恶性结节37例(42.05%)。弹性成像技术最终确诊85例,与手术组织检查诊断符合率为96.59%(P>0.05)。观察组甲状腺结节患者TSH,fT3,fT4及fT3/fT4水平均高于对照组健康体检者(P<0.05);观察组良性结节患者中TSH,fT3,fT4及fT3/fT4水平均低于恶性结节患者(P<0.05)。ROC曲线结果表明:弹性成像技术联合甲状腺激素在甲状腺结节患者诊断敏感性、特异性均高于单一弹性成像技术、甲状腺激素(P<0.05)。结论:弹性成像技术联合甲状腺激素用于甲状腺结节能帮助患者确诊,获得较高的诊断敏感性、特异性。

Objective:To investigate the effect of elastography combined with thyroid hormone in the diagnosis of thyroid nodules and the influence on the ROC curve.Methods:Eighty-eight patients with suspected thyroid nodule from March 2018 to June 2019 were selected as the study group.All patients were confirmed by puncture and operation.Before diagnosis,all patients completed elastic imaging technology measurement;thyroid hormone(TSH)level was measured by full-automatic chemiluminescence method;57 healthy people were selected as the control group;ROC curve was drawn.The diagnostic sensitivity and specificity of elastography combined with TSH in patients with thyroid nodules was analyzed.Results:Of the 88 suspected thyroid nodules,51 were benign(57.95%)and 37 were malignant(42.05%).Eighty-five cases were finally diagnosed by elastic imaging technology,the coincidence rate with the diagnosis of surgical tissue was 96.59%(P>0.05);the TSH,fT3,fT4 and fT3/fT4 levels of thyroid nodule patients in the observation group were higher than those of the control group(P<0.05);the TSH,fT3,fT4 and fT3/fT4 levels of benign nodule patients in the observation group were lower than those of malignant nodule patients(P<0.05);the ROC curve results showed that:elastic formation The diagnostic sensitivity and specificity of imaging combined with thyroid hormone in patients with thyroid nodules were higher than that of single elastic imaging and thyroid hormone(P<0.05).Conclusion:The combination of elastography and thyroid hormone can help the diagnosis of thyroid nodule,and can obtain high sensitivity and specificity.