血清IGF-1,5-HT及TNF-α水平与帕金森病伴发抑郁的相关性

Correlation between serum IGF-1,5-HT and TNF-αlevels and Parkinson’s disease with depression

目的:探究血清胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)、5-羟色胺(serotonin,5-HT)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平与帕金森病(Parkinson’s disease,PD)伴发抑郁的相关性。方法:选取辽阳市中心医院2018年1月至2019年12月收治的PD伴发抑郁患者40例为抑郁组,并选取同期无抑郁的PD患者40例与健康体检人员40例分别为PD组与对照组。抽血测定各组血清IGF-1,5-HT及TNF-α水平。采用Pearson相关性分析研究血清指标与伴发抑郁的关系,采用logistic回归分析研究PD伴发抑郁的相关因素。结果:抑郁组、PD组与对照组血清IGF-1,5-HT及TNF-α水平比较差异均有统计学意义(P<0.05),抑郁组患者血清IGF-1和5-HT水平均显著低于对照组与PD组(P<0.05),TNF-α水平高于对照组与PD组(P<0.05);汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)评分与血清IGF-1和5-HT水平呈负相关(P<0.001),与TNF-α水平正相关(P<0.001);血清IGF-1,5-HT与TNF-α水平呈负相关(P<0.05);logistic回归分析显示:受教育时间长、血清IGF-1和5-HT水平高是PD伴发抑郁的保护因素(P<0.05),病程长、血清TNF-α水平高是其危险因素(P<0.05)。结论:PD伴发抑郁患者血清IGF-1,5-HT低水平,TNF-α高水平,其危险因素包括病程长、高TNF-α水平、低IGF-1和5-HT水平。

Objective:To explore the correlation between serum insulin-like growth factor-1(IGF-1),serotonin(5-HT)and tumor necrosis factor-α(TNF-α)levels and Parkinson’s disease(PD)with depression.Methods:A total of 40 patients with PD complicated with depression who were admitted to the hospital between January 2018 and December 2019 were selected and included in the depression group.Meanwhile,40 patients with PD and without depression,and 40 healthy persons were selected and included in the PD group and the control group,respectively.Serum IGF-1,5-HT and TNF-αlevels in each group were determined.The relationship between serum indicators and depression was analyzed by Pearson correlation analysis.Logistic regression analysis was performed to analyze related factors of PD with depression.Results:There were significant differences in serum IGF-1,5-HT and TNF-αlevels between the depression group,the PD group,and the control group(P<0.05).Serum IGF-1 and 5-HT levels in the depression group were significantly lower than those in the control group and the PD group(P<0.05),but the level of TNF-αwas higher than the control group and the PD group(P<0.05).Hamilton Depression Scale(HAMD)score was negatively correlated with serum IGF-1 and 5-HT levels(P<0.001),but was positively correlated with TNF-αlevels(P<0.001).Serum IGF-1 and 5-HT levels were negatively correlated with TNF-αlevels(P<0.05).Logistic regression analysis showed that time of receiving education,high serum IGF-1 and 5-HT levels were protective factors for PD with depression(P<0.05),while long course of disease and high serum TNF-αlevels were risk factors(P<0.05).Conclusion:Serum IGF-1 and 5-HT levels are low and TNF-αlevel is high in patients with PD complicated with depression.Risk factors include long course of disease,high TNF-αlevel,low IGF-1 and 5-HT levels.