突变型p53调节蛋白在淋巴瘤中作用的研究进展

Research advance on the role of mutant type p53 regulatory protein in lymphoma

肿瘤抑制因子p53在维持细胞正常生长及抑制细胞恶性增殖过程发挥重要作用。当发生突变后形成突变型p53,其表达产物MTp53(mutant type p53)即失去原有的抑癌作用,导致细胞内信号通路紊乱,p53扮演的控制细胞增殖和凋亡的开关作用消失,细胞发生癌变,此过程受多种调节蛋白的影响。

Tumor suppressor p53 plays an important role in maintaining normal cell growth and inhibiting cell malignant proliferation.When mutant type p53 is formed,its expression product,mutant type p53 loses original anti-tumor effect and leads to the disorder of intracellular signal pathway.p53 acts as a switch to control cell proliferation and apoptosis,and cells become cancerous,which is affected by a variety of regulatory proteins.