益气活血法治疗气虚血瘀型脑梗死合并急性肾损伤疗效观察及对血清胱抑素C水平的影响

Effect of Yiqi Huoxue therapy on therapeutic efficacy and serum cystatin C level of cerebral infarction-caused acute kidney injury of qi-deficiency and blood-stasis syndrome

目的:观察益气活血法对气虚血瘀型脑梗死合并急性肾损伤的临床疗效,及其对血清胱抑素C(Cystatin C,CysC)水平的影响。方法:将104例气虚血瘀型脑梗死合并急性肾损伤患者随机分为两组,对照组52例予常规西药治疗,治疗组52例在对照组基础上加用补阳还五汤,连续用药14天。观察两组治疗前后美国国立卫生研究院卒中量表评分(NIHSS)、CysC水平和血肌酐、尿素氮指标,评估两组治疗疗效。结果:治疗14d后,治疗组总有效率(94.2%)显著高于对照组(86.5%)(P﹤0.05);治疗组CysC水平低于对照组(P﹤0.01);治疗组Scr、BUN指标和NIHISS评分改善均优于对照组(P﹤0.05)。结论:益气活血法治疗气虚血瘀型脑梗死合并急性肾损伤患者临床效果显著,中西医联合用药治疗较单纯西药治疗有更好的临床疗效。

Objective:To observe the clinical efficacy of Yiqi Huoxue therapy on cerebral infarction-caused acute kidney injury of qi-deficiency and blood-stasis syndrome and the effect on serum cystatin C level after treatment.Methods:104 cases of patients with cerebral infarction-caused acute kidney injury of qi-deficiency and bloodstasis syndrome were randomly divided into two groups,52 cases in each group.The control group was treated with conventional western medicine,while the treatment group was treated plus with Buyang Huanwu decoction on the basis of control group,continuously for 14 days.The indexes such as National institutes of health stroke scale(NIHSS),CysC level,serum creatinine(Scr)and blood urea nitrogen(BUN)were observed in two groups before and after treatment.The therapeutic efficacy was evaluated in two groups.Results:After 14 d of treatment,by rank-sum test of ordered categorical data,the total effective rate of treatment group was significantly better than that of control group(P﹤0.05).CysC level of treatment group was lower than that of control group(P﹤0.01).The improvement of Scr,BUN and NIHISS score in treatment group was better than in control group(P﹤0.05).Conclusion:The clinical efficacy of Yiqi Huoxue therapy on cerebral infarction-caused acute kidney injury of qi-deficiency and blood-stasis syndrome is significant.The clinical efficacy of integrated therapy of traditional Chinese and western medicine is better than that of simple western medicine.