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育龄期鼻咽癌女性患者生育情况及意愿的调查研究

Investigation of fertility and willingness of female patients with nasopharyngeal carcinoma in childbearing age
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摘要 目的调查并分析育龄期鼻咽癌女性患者的生育情况及生育意愿。方法选择1996年1月至2018年1月期间于中山大学肿瘤防治中心鼻咽科就诊的育龄期鼻咽癌女性患者,采用现场或电话询问的方法,调查鼻咽癌患者的生育情况及生育意愿,根据研究内容及要求共设立5个调查问题,包括:分娩次数、治疗后是否妊娠、妊娠及分娩过程是否存在并发症及合并症、新生儿出生和发育情况及将来的生育意愿。此外,通过医院病历系统对患者的基本信息资料、病理学类型及治疗方案等进行检索并分析。结果总共有142人纳入本调查研究,其中现有生存人数108人,死亡人数34人,分别占总调查人数的76.1%和23.9%。鼻咽癌患者接受的主要治疗方案有诱导联合同期放化疗和同期放化疗,占总治疗方案的47.9%和25.4%。按照生育情况,有105例患者在就诊时已生育过,37例患者从未生育,分别占调查总人数的73.9%和26.1%。108例现存活的患者中,有4人(3.7%)有继续生育的意愿,104人(96.3%)近期无生育计划,其中1人在经过治疗后成功分娩,分娩和新生儿出生及发育未见异常。此外,患者的生育意愿及结局与化疗药物的用量无明显相关性。结论育龄期鼻咽癌女性患者大部分已具有生育史,但无生育的患者超过总人数的五分之一,如何正确指导该群体的生育并进行生殖健康教育,对于提高年轻鼻咽癌女性患者的生活质量具有重要的现实意义。 Objective To investigate and analyze the fertility status and fertility intention of female patients with nasopharyngeal carcinoma(NPC)of childbearing age.Methods Female patients diagnosed with NPC in child-bearing age who were treated in the Department of Nasopharynx in the Sun Yat-sen University Cancer Center from January 1996 to January 2018 were selected and interviewed by on-site or telephone inquiry.According to the research contents and requirements,five survey questions were set up,including:gravidity,pregnancy after treatment,process of pregnancy and delivery,birth and development of the newborn,and intention of birth in the future.In addition,the basic information,pathological type and treatment plan of patients were retrieved and analyzed through the hospital medical record system.Results A total of 142 cases were included in this study.Among them,108 survived and 34 died,accounting for 76.1%and 23.9%respectively.Induction combined with concurrent chemoradiotherapy and concurrent chemoradiotherapy were the main treatment options for NPC patients,accounting for 47.9%and 25.4%of the total treatment regimens.According to the fertility status,105 patients had given birth at the time of treatment,and 37 patients had never given birth,accounting for 73.9%and 26.1%of the total number of patients respectively.Among the 108 surviving patients,4(3.7%)had the desire to continue to give birth,104(96.3%)had no family planning in the near future,and 1 patient had successfully delivered after treatment,and the birth and development of newborns were not abnormal.In addition,there was no significant correlation between fertility intention and outcome and the dosage of chemotherapy medications.Conclusions Most of the female patients with nasopharyngeal carcinoma of childbearing age have a history of childbearing,but more than one fifth of the total number of patients have no fertility.How to guide the group’s fertility and carry out reproductive health education correctly has important practical significance for improving the quality of life of young female patients with NPC.
作者 王聪 谢瑶 胡雯 范育英 陈林敏 WANG Cong;XIE Yao;HU Wen;FAN Yu-ying;CHEN Lin-min(Department of Nasopharyn,Sun Yat-sen University Cancer Center,Guangzhou510060,China)
出处 《妇产与遗传(电子版)》 2020年第4期19-23,共5页 Obstetrics-Gynecology and Genetics (Electronic Edition)
基金 广东省卫生健康委科研基金(A2020113) 中山大学护理青年人才培育基金(N2017Y04)。
关键词 鼻咽肿瘤 育龄女性 生育情况 生育意愿 Nasopharyngeal neoplasms Women of childbearing age Reproductive outcome Fertility intention
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