静脉滴注头孢替唑钠致突发性耳聋

Sudden deafness due to intravenous infusion of ceftezole sodium

1例58岁男性患者因尿路感染和前列腺炎给予头孢替唑钠2 g静脉滴注、2次/d。首次用药约20 min时,患者出现一过性右耳闷塞感和耳鸣,输液结束后,右耳耳鸣症状复现;第2次静脉滴注头孢替唑钠约25 min时,患者出现双耳耳鸣、双耳针刺样疼痛、听力下降及眩晕等症状。耳鼻喉科医师会诊后诊断为突发性耳聋,考虑为药物引起。停用头孢替唑钠,给予注射用前列地尔10μg入5%葡萄糖注射液100 ml静脉滴注、1次/d。8 d后患者耳鸣、耳痛、听力下降及眩晕等症状消失。

A 58‑year‑old male patient received intravenous infusion of ceftezole sodium 2 g twice daily for urinary tract infection and prostatitis.About 20 minutes in the first medication,the patient developed transient stuffy,plugged‑up sensation and tinnitus in the right ear.After finishing the first IV infusion,the tinnitus in the right ear recurred.About 25 minutes in the second IV infusion of ceftezole sodium,the patient developed tinnitus and stabbing pain in both ears,hearing loss,and dizziness.After consultation with otolaryngologists,the patient was diagnosed as having sudden deafness,which was considered to be caused by drug.Ceftezole sodium was stopped and an IV infusion of alprostadil for injection 10μg dissolved in 5%glucose injection 100 ml once daily was given.Eight days later,the patient′s symptoms such as tinnitus,earache,hearing loss,and dizziness disappeared.