乳酸左氧氟沙星氯化钠注射液致固定型药疹

Fixed drug eruption due to levofloxacin lactate and sodium chloride injection

1例78岁男性冠状动脉粥样硬化性心脏病患者行经皮冠状动脉介入治疗后发生肺部感染,给予乳酸左氧氟沙星氯化钠注射液0.6 g静脉滴注、1次/d和注射用头孢米诺钠2 g静脉滴注、1次/12 h抗感染治疗。首次用药8 h后,患者颈部及四肢出现红褐色、圆形、高出皮肤的皮疹。患者有服用环丙沙星后出现药疹的病史。皮肤科医师会诊后诊断为固定型药疹,考虑与乳酸左氧氟沙星氯化钠注射液有关。停用该药,继续使用头孢米诺钠并给予抗过敏治疗。7 d后,患者皮疹消退。

A 78⁃year⁃old male patient with coronary atherosclerotic heart disease received intra⁃venous infusions of levofloxacin lactate and sodium chloride injection 0.6 g once daily and cefminox sodium for injection 2 g once per 12 hours for pulmonary infection after percutaneous coronary intervention.Eight hours after the first medication,round reddish brown rashes,which were higher than the skin surface,appeared on the patient′s neck and limbs skin.The patient had a history of drug eruption after taking cipro⁃floxacin.After consultation with dermatologists,the patient was diagnosed as having fixed drug eruption,which was considered to be related to levofloxacin lactate and sodium chloride injection.Then the drug was discontinued and cefminox sodium was continued.At the same time,antiallergic treatment was given.Seven days later,the patient′s rash was subsided.