卡前列素氨丁三醇在预防前置胎盘剖宫产产后出血中的应用

Application of carprost tromethamine in preventing postpartum hemorrhage after cesarean section for placenta previa

目的探究卡前列素氨丁三醇预防前置胎盘剖宫产产后出血的临床效果。方法将2017年1月~2019年12月我院收治的48例前置胎盘剖宫产产妇采取抽签法随机分为试验组(n=24)和对照组(n=24),对照组产妇给予注射缩宫素、舌下含米索前列醇治疗,试验组在对照组基础上实施卡前列素氨丁三醇治疗。对比两组产妇产前及产后心率、收缩压、舒张压,产妇术中、术后2 h、术后24 h出血量,产妇出血控制效果及不良反应发生情况。结果两组产妇产前及产后2 h心率、收缩压、舒张压及不良反应发生率比较,差异无统计学意义(P>0.05);试验组产妇术中、术后2 h及术后24 h出血量均少于对照组,出血控制总有效率(95.83%)明显高于对照组(75.00%),差异有统计学意义(P<0.05)。结论卡前列素氨丁三醇应用于前置胎盘剖宫产预防产后出血效果显著,可有效降低手术出血量,值得推广。

Objective To explore the clinical effect of carprost tromethamine in preventing postpartum hemorrhage after cesarean section for placenta previa.Methods Forty-eight women with cesarean section for placenta previa admitted to our hospital from January 2017 to December 2019 were randomly divided into experimental group(n=24)and control group(n=24)by lottery method.The control group was treated with injection of oxytocin and sublingual misoprostol.The experimental group was treated with carprost tromethamine on the basis of the treatment in the control group.The prenatal and postpartum heart rate,systolic blood pressure,diastolic blood pressure,intraoperative blood pressure,2 h postoperative and 24 h postoperative blood loss,the effect of maternal bleeding control and the occurrence of adverse reactions were compared between the two groups.Results There was no significant difference in heart rate,systolic blood pressure,diastolic blood pressure and adverse reactions between the two groups before and 2 h after childbirth(P>0.05).The bleeding volume of the experimental group during surgery,2 h after surgery and 24h after surgery was lower than that of the control group,and the total effective rate of bleeding control(95.83%)in the experimental group was higher than that of the control group(75.00%),and the differences were statistically significant(P<0.05).Conclusion Carprost tromethamine used in placenta previa caesarean section has a significant effect in preventing postpartum hemorrhage,which can effectively reduce the amount of surgical bleeding,and is worthy of promotion.