微反应器技术细化CL-20方法研究

Study on Refining CL-20 by Micro-reactor Technology

采用微反应器技术细化CL-20,通过流体混合数值模拟研究微反应器的混合效果,确定微反应器的优化结构;通过实验研究溶剂乙酸乙酯和非溶剂正庚烷流速比、温度以及CL-20浓度对CL-20晶体形貌、晶型和粒度大小的影响。结果表明:在T型混合器的基础上增加4个圆腔,溶剂与非溶剂的混合效果更佳;在CL-20浓度为7.0%,溶剂流速0.2mL/min,非溶剂流速2mL/min,活性剂浓度2%,收集装置加热温度60℃时,重结晶CL-20的晶型为ε型,平均粒径为6.92μm,且颗粒均匀。

The micro reactor technology was used to refine CL-20,the mixing effect of micromixer was studied by numerical simulation of fluid mixing,and the optimal structure of micro-reactor was determined.Then ethyl acetate was used as solvent and n-heptane as nonsolvent,and the effects of solvent to non-solvent flow rate ratio,temperature and CL-20 concentration on the morphology,crystal form and particle size of CL-20 were studied experimentally.The results show that the mixing effect of solvent and nonsolvent is better by adding four circular cavities on the basis of T-mixer.When the concentration of CL-20 is 7.0%,the flow rate of solvent is 0.2mL/min,the flow rate of nonsolvent is 2mL/min,the concentration of active agent is 2%,and the temperature of the collecting device is 60℃,the crystal form of recrystallized CL-20 isεtype,the average particle size is 6.92μm,and the particles are uniform.