正常听力儿童及青年失匹配负波研究

Mismatch Negativity In Normal Children and Youth

目的探讨正常儿童及正常青年失匹配负波(mismatch negativity,MMN)的特点。方法对29例(58耳)正常听力儿童(7~16岁)及29例(58耳)正常听力青年(18~34岁)采用经典的oddball模式进行MMN检查,标准刺激和偏差刺激分别为1000 Hz和2000 Hz的短纯音,观察两组MMN潜伏期及波幅的特点,并比较两组的差异。结果58例(116耳)受试者均可正常引出MMN波形,正常儿童组MMN平均潜伏期和平均波幅分别为171.23±26.90 ms和3.46±2.30μV,正常青年组分别为177.57±26.61 ms和3.96±2.46μV;两组间MMN潜伏期及波幅均无统计学差异(P=0.072,P=0.11>0.05)。结论7~16岁正常听力儿童及18~34岁正常听力青年组均能引出稳定的MMN波形,且两组间MMN的潜伏期和波幅无明显差异;MMN结果与儿童受试者听觉通路的成熟情况有关,与年龄差异无关。

Objective To study the characteristics of mismatch negativity(MMN)in normal children and youth.Methods A total of 29 normal children and 29 normal young people were examined for MMN.The subjects in the two groups were tested for MMN with the classical oddball mode,standard stimulus and deviant stimulus of 1000 Hz and 2000 Hz.The characteristics of latency and amplitude of MMN in the two groups were observed and the differences between the two groups were compared.Results The 58 subjects could elicit MMN waveform normally.The average latency of MMN in the normal children group was 171.23±26.90 ms,and the average amplitude was 3.46±2.30μV.The average latency of MMN in the normal youth group was 177.57±26.61 ms.The average amplitude was 3.96±2.46μV.There was no significant difference in MMN latency and amplitude between the two groups(P=0.072,P=0.11>0.05).Conclusion Both normal children aged 7~16 and normal youth aged 18~34 can stably elicit MMN waveform,and there is no significant difference in the latency and amplitude of MMN between the two groups.