血清神经肽Y水平与绝经后妇女骨密度相关性研究

Correlation between serum neuropeptide Y levels and bone mineral density in postmenopausal women

目的探讨血清神经肽Y(NPY)水平与绝经后妇女骨密度(BMD)的相关性。方法纳入在我院门诊就诊的绝经后妇女。测量血清钙、磷、白蛋白、甲状旁腺激素(parathyroid hormone,PTH)、促甲状腺激素(thyrotropin,TSH)、25-OH维生素D和NPY浓度。根据骨密度检测结果将受试者分为3组,分别为BMD值:正常(n=66)、骨量减少(n=63)和骨质疏松症(n=63)。根据血清NPY水平,受试者也被分为3组:低NPY(n=30)、正常NPY(n=126)和高NPY(n=36)。结果骨密度正常、骨质疏松、骨质疏松症患者血清NPY、PTH和年龄水平差异有显著统计学意义(P<0.05)。对于不同的NPY水平,各组腰椎、股骨总、股骨颈、转子、股骨转子间和Ward’s三角BMD值有显著差异(P<0.05)。相关性分析显示血清NPY水平与患者年龄、BMI呈现显著正相关(P<0.05),与不同部位的BMD值之间均有显著负相关性(P<0.05)。结论血清NPY水平与患者年龄、体重指数或任何部位测量的BMD值之间有相关性。

Objective To investigate the relationship between serum neuropeptide Y(NPY)level and bone mineral density(BMD)in postmenopausal women.Methods This study included postmenopausal women who were treated in the outpatient clinic of our hospital.Serum calcium,phosphorus,albumin,parathyroid hormone(parathyroid hormone,PTH),thyroid stimulating hormone(thyrotropin,TSH),25-OH vitamin D,and NPY were measured.According to the result of bone mineral density,the subjects were divided into three groups:normal BMD(n=66),osteopenia(n=63),and osteoporosis(n=63).According to the serum NPY level,the subjects were also divided into three groups:low NPY(n=30),normal NPY(n=126),and high NPY(n=36).Results There were significant differences in serum NPY,PTH,and age in patients with normal BMD,osteopenia,or osteoporosis.For different NPY levels,there were significant differences in BMD of the lumbar vertebrae,total femur,femoral neck,trochanter,intertrochanteric,and Ward triangle among groups.Correlation analysis showed that the level of serum NPY was positively correlated with age and BMI,and was negatively correlated with BMD in different parts of the patients(P<0.05).Conclusion There is correlation between serum NPY levels and age,body mass index,and any measured BMD values in the patients.