速效救心丸治疗冠状动脉粥样硬化性心脏病的真实世界研究

Effects of Suxiao Jiuxin Pill in the Treatment of Coronary Atherosclerotic Heart Disease in the Real World

目的评价真实世界中速效救心丸治疗冠状动脉粥样硬化性心脏病的临床疗效。方法基于中国中医科学院中医临床基础医学研究所建立的37家三级甲等医院的信息管理系统(HIS)数据,以主要诊断为冠状动脉粥样硬化性心脏病病人为研究对象。以使用速效救心丸的病人为观察组,按照性别、年龄、入院病情并1∶1匹配对照组(未使用速效救心丸组),以用药疗效为结局评价指标,采用GBM倾向性评分法平衡两组间的混杂因素,再通过3种Logistic评分方法(单变量的Logistic回归、倾向性评分加权的Logistic回归、带协变量的倾向性评分加权的Logistic回归)比较两组间治疗冠状动脉粥样硬化性心脏病的疗效差异。结果采用带协变量的倾向评分加权Logistic回归(无未平衡的协变量),观察组治疗效果优于对照组(回归系数为-0.8510,P<0.05)。结论基于现有数据分析发现,使用速效救心丸治疗冠状动脉粥样硬化性心脏病比未使用速效救心丸治疗冠状动脉粥样硬化性心脏病的临床疗效更佳。

Objective To evaluate the clinical efficacy of Suxiao Jiuxin Pill in patients with coronary atherosclerotic heart disease in the real world.Methods Based on the data of 37 hospital information management systems(HIS)established by the Institute of Traditional Chinese Medicine and Basic Medicine of the Chinese Academy of Chinese Medical Sciences,the patients diagnosed with coronary atherosclerotic heart disease were taken as the research objects.The patients taking Suxiao Jiuxin Pill were used as the observation group,and the control group was matched according to gender,age,and hospitalization condition(without Suxiao Jiuxin Pill group).The efficacy of the medication was used as the outcome evaluation index.The GBM tendency score was used to balance the confounding factors between the two groups.The efficacy difference was compared by three logistic scoring methods(univariate logistic regression,weighted logistic regression with propensity score,and propensity score weighted logistic regression with covariates)for the treatment of coronary atherosclerotic heart disease between the two groups.Results The therapeutic effect of observation group was better than that of control group(the regression coefficient was-0.8510,P<0.05).Conclusion Based on the available data,it can be found that the use of Suxiao Jiuxin Pills for the treatment of coronary atherosclerotic heart disease is better than that without Suxiao Jiuxin Pills for the treatment of coronary atherosclerotic heart disease.