老老年高血压病人夜间收缩压下降率与碱性磷酸酶的相关性

The Correlation between the Decrease Rate of Nocturnal Systolic Blood Pressure and Alkaline Phosphatase in Very Elderly Patients with Hypertension

目的分析老老年高血压病人夜间收缩压下降率与碱性磷酸酶之间的相关性。方法选取老老年原发性高血压病人240例,根据夜间收缩压下降率不同将病人分为3组,反杓型组127例,非杓型组71例,杓型组42例。比较3组碱性磷酸酶水平及常规生化指标。结果碱性磷酸酶水平反杓型组(75.04±23.67)U/L<非杓型组(81.07±35.53)U/L<杓型组(91.42±29.48)U/L,杓型组高于反杓型组,差异有统计学意义(P<0.05)。相关性分析结果显示:夜间收缩压下降率与碱性磷酸酶、高密度脂蛋白胆固醇、血尿素氮水平存在相关性。多元线性逐步回归分析结果显示碱性磷酸酶水平与夜间收缩压下降率关系密切。结论碱性磷酸酶在老老年高血压病人临床诊断中具有一定的临床意义,应予以重视。

Objective To observe the correlation between the decrease rate of nocturnal systolic blood pressure and alkaline phosphatase in very elderly patients with hypertension.Methods Two hundred and forty very elderly patients with essential hypertension were divided into 3 groups according to the decrease rate of nocturnal systolic blood pressure,with 127 cases in the anti-dipper group,71 cases in the non-dipper group,and 42 cases in the dipper group.Alkaline phosphatase and biochemical indicators were compared between three groups.Results The alkaline phosphatase in the anti-dipper group was(75.04±23.67)U/L<that in the non-dipper group(81.07±35.53)U/L<that in the dipper group(91.42±29.48)U/L,the difference was statistically significant(P<0.05).The result of analysis showed that the decrease rate of nocturnal systolic blood pressure was significantly correlated with alkaline phosphatase,high-density lipoprotein,uric acid,and blood urea nitrogen levels.The multivariate linear stepwise regression analysis showed that the level of alkaline phosphatase was most closely related to the decrease rate of nocturnal systolic blood pressure.Conclusion Alkaline phosphatase had certain clinical significance in the clinical diagnosis of very elderly patients with hypertension and should be paid more attention to it.