肝移植肠道微生态研究进展

Research progress of intestinal microecology in liver transplantation

肠道微生态是人体最重要的微生态系统,由肠道内大量菌群和它们生活的环境共同组成。肠道微生态与人体免疫及代谢功能相关,是肠-肝循环的重要媒介。在肝移植人群中,由于肝病本身及肝移植手术的影响,肠道微生态会发生改变,这种改变将直接影响移植肝功能恢复。目前,如何通过调节肠道微生态来促进肝移植病人术后恢复尚处于探索阶段。本文将就肝移植病人肠道微生态变化,肠道微生态与肝移植术后并发症的关系,肠道微生态调节方案及其对肝移植人群术后恢复影响等方面作一综述。

Intestinal microecology is the most important microecosystem of human body,which is composed of a large number of intestinal microflora and their living environment.Intestinal microecology is related to human immune and metabolic function,and is an important media of gut-liver circulation.In the liver transplant population,because of the liver disease itself and the liver transplant operation influence,the intestinal microecology will have the change,this kind of change will directly affect the transplant liver function recovery.At present,how to adjust the intestinal microecology to promote the postoperative recovery of liver transplantation patients is still in the exploratory stage.This article reviews the changes of intestinal microecology in liver transplant patients,the relationship between intestinal microecology and complications after liver transplantation,and the effect of Intestinal microecological regulation program on postoperative recovery of liver transplant patients.The aim of this study was to reveal the importance of intestinal microecology and to provide reference for the future perioperative intestinal treatment of liver transplantation.