摘要
Orthostatic intolerance(OI)is characterized by symptoms and signs of dizziness,headache,visual difficulties,a loss of consciousness,nausea,abdominal discomfort,pallor,tachycardia or hypotension;and OI is primarily elicited by a rapid postural change from supine to standing or prolonged quiet standing which can be resolved by lying down[1,2].About 15%of children and adolescents are affected by OI,with the median peak age of the first OI onset at 15 years[3].OI accounts for a noticeable proportion of emergency department visits.Deliberately or indeliberately,the injection of normal saline always plays a role,which“rescues”the patients.Single or occasional episodes of OI are often overlooked by some patients;and children with recurrent OI symptoms often experience depression,and have diminished quality of life。
基金
This work was supported by Science and Technology Program of Beijing(No.Z171100001017253)
Peking University Clinical Scientist Program(No.BMU2019LCKXJ001)
Peking University Medicine Fund of Fostering Young Scholars,Scientific and Technological Innovation,Peking University Clinical Medicine Plus X-Young Scholars Project(No.PKU2019LCXQ011),and Fundamental Research Funds for the Central Universities.