燥湿化痰饮辅助治疗脑卒中后认知障碍的效果研究

Study on Effect of Zaoshi Huatan Yin in Treatment of Cognitive Impairment after Stroke

目的研究燥湿化痰饮辅助治疗脑卒中后认知障碍的效果。方法选取医院2016年2月—2019年1月收治的脑卒中后认知障碍患者82例,分为两组。所有患者均给予常规对症治疗,并给予言语认知训练,观察组给予燥湿化痰饮辅助治疗,分析两组患者治疗后的临床疗效。结果观察组总有效率为92.68%(38/41),对照组为75.61%(31/41),观察组患者总有效率高于对照组(P<0.05)。两组治疗前蒙特利尔认知评估量表(MoCA)评分、简易智能检查量表(MMSE)评分组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后MoCA评分(26.98±3.01)分、MMSE评分(24.96±3.41)分高于对照组(P<0.05)。两组治疗前超氧化物歧化酶(SOD)、丙二醛(MDA)、神经生长因子(NGF)水平组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后SOD、NGF水平高于对照组,MDA水平低于对照组(P<0.05)。两组治疗前外周血单个核细胞相关miRNA水平组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后miRNA-124、miRNA-134表达水平低于对照组(P<0.05)。结论燥湿化痰饮可调节脑卒中后认知障碍患者外周血单个核细胞相关miRNA水平,减轻氧化应激损伤,改善认知功能,提高近期疗效。

Objective To study the effect of Zaoshi Huatan Yin on cognitive impairment after stroke. Methods Eighty-two patients with post-stroke cognitive impairment treated in our hospital from February 2016 to January 2019 were divided into two groups. All patients were given routine symptomatic treatment and speech cognitive training, while the observation group was given auxiliary treatment of Zaoshi Huatan Yin. The clinical efficacy of the two groups after treatment was analyzed. Results The total effective rate was 92.68%(38/41) in the observation group and 75.61%(31/41) in the control group. The total effective rate in the observation group was higher than that in the control group(P<0.05). The MoCA score before treatment was higher in the two groups. There was no significant difference in the MMSE score between the two groups(P>0.05). After treatment, the MoCA score and MMSE score in the observation group were 26.98±3.01 and 24.96±3.41, respectively, which were higher than those in the control group(P<0.05). The malondialdehyde(MDA) and SOD in the two groups before treatment were higher than those in the control group(P<0.05). There was no significant difference in the level of nerve growth factor(NGF) between the two groups(P>0.05). After treatment, the levels of SOD and NGF in the observation group were higher than those in the control group, and the level of MDA in the observation group was lower than that in the control group. There was no significant difference in the level of miRNA related to peripheral blood mononuclear cells between the two groups before treatment(P>0.05). The expression levels of miRNA-124 and miRNA-134 in the observation group were lower than those in the control group after treatment. Conclusion Zaoshi Huatan Yin can regulate the level of miRNA associated with peripheral blood mononuclear cells in patients with cognitive impairment after stroke, reduce oxidative stress injury and improve cognitive function and the short-term curative effect.