黄药子肝毒性及减毒配伍研究进展

Research Development of Liver Toxicity and Toxicity Alleviation of Huangyaozi(Dioscorea bulbifera)

黄药子药用历史悠久,在治疗甲状腺疾病、恶性肿瘤等疑难病中疗效显著,但其肝毒性使得黄药子的临床运用受到极大限制。近年来关于黄药子肝毒性的毒理学和减毒配伍研究较多,从代谢激活、氧化应激、线粒体损伤和细胞凋亡等方面对黄药子的肝毒性机制作总结,归纳了当归、甘草、黄芩等药物减轻黄药子肝毒性机制,以期为后来的基础研究和黄药子的临床应用提供参考。

Huangyaozi(Dioscorea bulbifera) has a long history of use in China and it is effective in the treatment of difficult diseases such as thyroid diseases and malignant tumors. But its hepatotoxicity makes the clinical application of Huangyaozi(Dioscorea bulbifera) extremely limited. In recent years, there are many studies on the toxicology and toxicity alleviation of hepatotoxicity of Huangyaozi(Dioscorea bulbifera). This article summarized the hepatotoxic mechanism of Huangyaozi(Dioscorea bulbifera) from metabolic activation, oxidative stress, mitochondrial damage and apoptosis. It also summarized the mechanisms of Danggui(Angelica sinensis), Gancao(Glycyrrhiza uralensis), Huangqin(Scutellaria baicalensis) and other drugs to reduce the hepatotoxicity of Huangyaozi(Dioscorea bulbifera) in order to provide reference for the later basic research and clinical application of Huangyaozi(Dioscorea bulbifera).