小儿肺咳颗粒联合红霉素治疗小儿毛细支气管炎疗效及对CRP、IL-6和WBC水平影响

Effect of Feike Granules Combined with Erythromycin on CRP, IL-6 and WBC in Children with Bronchiolitis

目的探讨小儿肺咳颗粒联合红霉素治疗小儿毛细支气管炎的疗效及对CRP、IL-6和WBC水平影响。方法选取医院治疗的82例毛细支气管炎患儿,随机分为两组各41例。对照组患儿给予静脉滴注注射用乳糖酸红霉素,实验组在对照组基础上口服小儿肺咳颗粒,两组患儿均持续治疗10 d。对比两组患儿的临床疗效、临床症状消失时间和不良反应。对比两组患儿治疗前后肺功能指标水平、毛细支气管炎严重度评分、临床症状评分及血清白介素-6(IL-6)、白细胞计数(WBC)、C反应蛋白(CRP)水平变化。结果治疗后,实验组总有效率较高(P<0.05);实验组患儿患儿气喘、呼吸困难、咳嗽、湿性罗音、喘鸣音消失时间及住院时间显著低于对照组(P<0.05);两组患儿治疗后Ti/Te、RR水平显著降低,tPTEF/tE和VT水平显著升高(P<0.05);并且实验组改善较多(P<0.05);两组患儿治疗前毛细支气管炎严重度评分差异无统计学意义(P>0.05);两组患儿治疗3、5、7 d后毛细支气管炎严重度评分明显低于对照组(P<0.05);两组患儿治疗前临床症状评分差异无统计学意义(P>0.05);两组患儿治疗后喘息、咳痰、咳嗽等症状明显降低(P<0.05);并且实验组降低较多(P<0.05);两组患儿治疗后CRP、IL-6和WBC水平明显降低(P<0.05);并且实验组CRP、IL-6和WBC水平低于对照组(P<0.05)。结论采用小儿肺咳颗粒联合红霉素治疗小儿毛细支气管炎具有较好的治疗效果,能够改善患儿临床症状,安全性较高,值得在临床上推广应用。

Objective To investigate the effect of Feike Granules combined with erythromycin on the levels of CRP and IL-6 and WBC in the treatment of children bronchiolitis. Methods Eighty-two cases of bronchiolitis in our hospital were randomly divided into two groups, 41 cases in each. The children in the control group were given intravenous infusion of erythromycin lactate, and the children in the experimental group were given oral administration of Feike Granules on the basis of the control group. The children in the two groups were treated continuously for 10 days. The clinical efficacy, symptom disappearance time and adverse reactions of the two groups were compared. The levels of pulmonary function, severity score of bronchiolitis, clinical symptom score, serum interleukin-6(IL-6), WBC and CRP were compared before and after treatment in the two groups. Results After treatment, the total effective rate of the experimental group was higher(P<0.05). The time of disappearance of wheezing, dyspnea, cough,moist rales,wheezing and hospitalization in the experimental group was significantly shorter than that in the control group(P<0.05). After treatment, the levels of Ti/Te and RR in the two groups were significantly decreased, while the levels of tPTEF/Te and VT were significantly increased(P<0.05). And those of the experimental group improved more obviously(P<0.05). There was no difference in the severity score of bronchiolitis before treatment between the two groups(P>0.05). The severity score of bronchiolitis was significantly lower in the two groups after treatment on 3 d, 5 d and 7 d than those in the control group(P<0.05). There was no difference in clinical symptom score between the two groups before treatment(P>0.05). After treatment, the symptoms of wheezing, coughing and coughing were significantly reduced in both groups(P<0.05). There was a significant decrease in the experimental group(P<0.05). After treatment, levels of CRP, IL-6 and WBC were significantly decreased in both groups(P<0.05). Moreover, levels of CRP, IL-6 and WBC in the experimental group were lower than those in the control group(P<0.05). Conclusion The treatment of pediatric bronchiolitis with Feike Granules combined with erythromycin has good therapeutic effect and can improve the clinical symptoms of children with high safety, worthy of clinical application.