Cell-derived biomimetic nanoparticles as a novel drug delivery system for atherosclerosis:predecessors and perspectives

Atherosclerosis is a key mechanism underlying the pathogenesis of cardiovascular disease,which is associated with high morbidity and mortality.In the field of precision medicine for the treatment of atherosclerosis,nanoparticle(NP)-mediated drug delivery systems have great potential,owing to their ability to release treatment locally.Cell-derived biomimetic NPs have attracted extensive attention at present due to their excellent targeting to atherosclerotic inflammatory sites,low immunogenicity and long blood circulation time.Here,we review the utility of cell-derived biomimetic NPs,including whole cells,cell membranes and extracellular vesicles,in the treatment of atherosclerosis.