侵袭性肺部真菌感染采用卡泊芬净治疗的疗效及安全性研究

Efficacy and safety of capprofen in treatment of invasive pulmonary fungal infection

目的分析醋酸卡泊芬净治疗侵袭性肺部真菌感染应用的临床效果。方法选取2018年1月至2020年2月新乡市中心医院收治的侵袭性肺部真菌感染患者100例,采用随机数字表法分为两组,各50例,对照组患者采用伊曲康唑,研究组给予醋酸卡泊芬净治疗,比较两组临床治疗效果、真菌清除率以及不良反应情况。结果研究组治疗总有效率为96.00%,对照组有效率为78.00%,差异有统计学意义(P<0.05)。研究组治疗后真菌清除率为88.46%,与对照组(64.71%)比较,P<0.05。研究组与对照组不良反应发生率分别为8.00%和30.00%,差异有统计学意义(P<0.05)。结论醋酸卡泊芬净应用于侵袭性肺部真菌感染患者,可有效提升患者的真菌清除效果,临床效果显著,且不良反应少,安全性高,值得推广应用。

Objective To analyze the clinical effect of treating invasive pulmonary fungal infection with carpofine acetate.Methods Between January 2018 and January 2020,our hospital 100 cases of invasive pulmonary fungal infection patients,using the random number table method was divided into equal the number of cases in the two groups,each 50 cases,control group were treated by Itraconazole,research group were treated by Carpafine acetate,compared two groups of clinical curative effect,fungal clearance and adverse reactions.Results The total effective rate was 96.00%in the study group and 78.00%in the control group,the difference was statistically significant(P<0.05).The rate of fungal clearance after treatment in the study group was 88.46%,compared with 64.71%in the control group(P<0.05).The incidence of adverse reactions in the study group and the control group were 8.00%and 30.00%,respectively,with statistically significant differences(P<0.05).Conclusion The application of carpofine acetate in patients with invasive pulmonary fungal infection can effectively improve the efficacy of fungal clearance,and the clinical effect is significant,with fewer adverse reactions and high safety.