帕罗西汀对重症肌无力危象患者脱机时间的影响

Effect of Paroxetine on time to leave ventilator in patients with myasthenia gravis crisis

目的观察帕罗西汀对重症肌无力危象患者脱机时间的影响。方法选取河南省人民医院神经内科ICU病房2014年11月—2019年9月收治的60例重症肌无力危象患者,随机数字法将其分为治疗组(30例)和对照组(30例)。治疗组自呼吸机辅助呼吸次日给予帕罗西汀,连续服用3个月,参照相关指南两组均接受糖皮质激素、免疫球蛋白、溴吡斯的明等治疗,比较两组患者的间断脱机时间和完全脱机时间的差异。结果治疗组脱机时间明显短于对照组(P<0.05)。结论帕罗西汀可降低重症肌无力危象患者的焦虑情绪,减少呼吸机依赖的发生率,可有效缩短重症肌无力危象患者的脱机时间,降低患者的医疗费用。

Objective To observe the effect of Paroxetine on the time to leave the ventilator in patients with myasthenia gravis crisis.Methods A selection of 60 patients with myasthenia gravis crisis admitted to the Neurological Intensive Care Unit of Henan Provincial People’s Hospital from November 2014 to September 2019 were divided into treatment group(30 cases)and control group(30 cases)by random number method.The treatment group was given Paroxetine from the ventilator-assisted breathing the next day for 3 months.According to relevant guidelines,both groups received glucocorticoid,immunoglobulin,bropistigmine and other treatments,then we compare the difference between the intermittent weaning time and the complete weaning time of the two groups of patients.Results The intermittent weaning time and the complete weaning time of the treatment group were significantly shorter than those of the control group(P<0.05).Conclusion Paroxetine can reduce the anxiety of patients with myasthenia gravis crisis,reduce the incidence of ventilator dependence,can effectively shorten the offline time of patients with myasthenia gravis crisis,and reduce the medical expenses of patients.