围手术期白介素17水平在膀胱尿路上皮细胞癌预后中的意义研究

Significance of perioperative interleukin 17 levels in prognosis of uroepithelium cell carcinoma of bladder

目的探讨白介素17(IL-17)水平在膀胱尿路上皮细胞癌(UCCB)预后中的意义。方法收集郑州人民医院2014年6月至2018年4月收治的经TURBT手术治疗的UCCB病例94例,检测其外周血IL-17水平。分析血清IL-17水平与UCCB患者临床资料的相关性,采用单因素和多因素Cox回归分析血清中IL-17水平与UCCB患者无进展生存期(PFS)和总生存期(OS)的相关性。结果IL-17水平与UCCB患者G分级有一定相关性。生存分析结果显示,高IL-17水平组PFS、OS明显低于低IL-17水平组;Cox回归分析结果显示,高水平IL-17是UCCB患者PFS及OS的独立危险因素(P<0.05)。结论IL-17是影响UCCB患者预后的独立危险因素,可作为潜在的预后评估指标。

Objective To investigate the significance of interleukin17(IL-17)levels in the prognosis of uroepithelium cell carcinoma of bladder(UCCB).Methods Totally 94 cases of UCCB who were treated by TURBT surgery from June 2014 to April 2018 were collected and their peripheral blood IL-17 levels were detected.The correlation between serum IL-17 levels and clinical data of UCCB patients was analyzed.The correlation between serum IL-17 levels and progression free survival(PFS)and overall survival(OS)of UCCB patients was analyzed by univariate and multivariate Cox regression.Results There was a certain correlation between the level of IL-17 and G grade in patients with UCCB.The results of survival analysis showed that the PFS and OS in high IL-17 group were significantly lower than those in low IL-17 group.Cox regression analysis showed that high levels of IL-17 were an independent risk factors for PFS and OS in patients with UCCB(P<0.05).Conclusion IL-17 was an independent risk factor for the prognosis of patients with UCCB,which could be used as a potential prognostic indicator.