四项血清肿瘤标志物在胃癌早期诊断中联合检验的价值评价

Evaluation of four serum tumor markers in early diagnosis of gastric cancer

目的研究和讨论在胃癌诊断中应用CA724、CEA、CA242、CA199肿瘤标志物联合检验的临床应用效果与价值评价。方法选取本院2018年1月—2019年3月期间内接受诊治和体检的130例患者和体检人员共130例作为此次的研究对象。其中观察组中胃癌患者有61例;对照组中胃良性病变患者32例,体检结果为胃部健康状态者37例。观察组和对照组患者对两组患者进行CA724、CEA、CA242、CA199指标检查,比较两组患者肿瘤标志物指标。结果经检测之后,观察组胃癌患者的每类肿瘤标志物指标水平明显较对照组高;观察组中分化程度为低分化、肝转移情况为无肝转移以及临床分期为Ⅲ—Ⅳ期的胃癌患者每项肿瘤标志物被检测出阳性的概率比分化程度为中高度分化、有无肝转移情况为有肝转移以及临床分期为Ⅰ—Ⅱ期的胃癌患者高;肿瘤标志物的诊断当中,联合四种肿瘤标志物检测胃癌的灵敏度和特异度与一种肿瘤标志物、两种肿瘤标志物联合以及三种肿瘤标志物联合检测胃癌灵敏度和特异度相比,联合CA724、CEA、CA242、CA199四种肿瘤标志物诊断胃癌的灵敏度和特异度最高,灵敏度达94.17%,特异度达84.62%,数据之间对比和判定具有统计学意义(P<0.05)。结论将四种肿瘤标志物联合对受试者每项肿瘤标志物水平进行检测,能提升胃癌患者每类肿瘤标志物指标检测水平;提高胃癌患者的每类肿瘤标志物的阳性检测率;同时能提高诊断胃癌的灵敏度和特异度。对于临床医学来说,联合CA724、CEA、CA242、CA199对胃癌进行检测有较高的准确性,对胃癌患者的病情分析有着极高的参考价值,值得被临床广泛推广与应用。

Objective To study and discuss the clinical application effect and value evaluation of combined detection of tumor markers in CA724,CEA,CA242 and CA199 in the diagnosis of gastric cancer.Methods A total of 130 patients and physical examination patients who underwent medical examination and physical examination from January 20 to March 2019 in our hospital were selected as the study subjects.Among them,there were 61 patients with gastric cancer in the observation group,32 patients with benign gastric lesions in the control group,and 37 patients with physical examination results.The patients in the observation group and the control group were tested for CA724,CEA,CA242 and CA199 by specific chemical methods.The tumor markers were compared between the two groups.Results After the test,the level of each type of tumor marker in the observation group was significantly higher than that in the control group;The degree of differentiation in the observation group was poorly differentiated,the liver metastasis was no liver metastasis,and the clinical stage was stage III-IV gastric cancer.The probability of each tumor marker being positively detected is higher than that of patients with moderate to high degree of differentiation,with or without liver metastases in patients with liver metastasis and clinical stage I-II;In the diagnosis of tumor markers,combined The sensitivity and specificity of four tumor markers for detecting gastric cancer were compared with a tumor marker,two tumor markers combined with three tumor markers to detect the sensitivity and specificity of gastric cancer,combined with CA724,CEA,CA242,CA199 The sensitivity and specificity of tumor markers for the diagnosis of gastric cancer were the highest,the sensitivity was 94.17%,and the specificity was 84.62%.The comparison and determination between the data were statistically significant(P<0.05).Conclusion The combination of four tumor markers to detect the level of each tumor marker in the subject can improve the detection level of each type of tumor marker in gastric cancer patients,increase the positive detection rate of each type of tumor markers in gastric cancer patients,can improve the sensitivity and specificity of diagnosis of gastric cancer.For clinical medicine,combined with CA724,CEA,CA242,CA199 for the detection of gastric cancer has a high accuracy,has a very high reference value for the analysis of the disease of patients with gastric cancer,it is worthy of extensive clinical Promotion and application.