3D-ASL灌注成像与静息态功能MRI在癫痫诊断及鉴别中的价值

The Value of 3D-ASL Perfusion Imaging and Resting State MRI in Diagnosis and Differentiation of Epilepsy

选取123例癫痫患者作为研究组,同期69例健康体检者作为对照组,均行三维动脉自旋标记技术(3D-ASL)灌注成像与静息态功能MRI(rs-FMRI)检查,研究二者在癫痫病诊断及鉴别中的价值。结果发现,研究组全面发作脑血流量(CBF)、低频振幅(ALFF)<部分发作和对照组,全面发作血清脑源性神经细胞营养因子(BDNF)、胰岛素样生长因子-1(IGF-1)水平、认知功能(MMSE)评分<部分发作<对照组,血清神经肽Y(NPY)>部分发作>对照组(P<0.05),且癫痫患者CBF、ALFF与BDNF、IGF-1、MMSE呈正相关,与NPY呈负相关。CBF与ALFF联合在诊断癫痫发作、鉴别不同癫痫发作类型方面均具有较高应用价值。说明3D-ASL灌注成像及rs-FMRI在癫痫发作诊断及鉴别不同癫痫发作类型方面应用价值较高。

A total of 123 patients with epilepsy were selected as the research group,and 69 healthy physical examination subjects were selected as the control group during the same period,the value of two methods in diagnosis and differentiation of epilepsy was studied.All were performed with three-dimensional arterial spin labeling technique(3D-ASL)perfusion imaging and resting state functional magnetic resonance imaging(rs-FMRI)examination.It was found that the full-onset cerebral blood flow(CBF)and low-frequency amplitude(ALFF)of the research group<partial seizure<control group,the levels of serum brain-derived neurotrophic factor(BDNF),insulin-like growth factor-1(IGF-1),and cognitive function(MMSE)scores<partial seizure<control group,serum neuropeptide Y(NPY)>partial seizure>control group(P<0.05);and CBF and ALFF in patients with epilepsy were positively correlated with BDNF,IGF-1,MMSE,and negatively correlated with NPY.The combination of CBF and ALFF had high application value in diagnosing seizures and identifying different types of seizures.It can be seen that 3D-ASL perfusion imaging and rs-FMRI have high application value in the diagnosis and identification of seizure types.