核壳结构载药纤维的制备与研究

Preparation and study of drug loaded fiber with nuclear-shell structure

为了制备具有毒性小、污染少、药效高和残留少等优点的缓释纤维,首先以醋酸纤维素为药物缓释载体,以阿维菌素为释放农药,利用同轴静电纺丝技术制备了具有核壳结构的载药纤维,并对其结构和形貌进行了一系列的表征。阿维菌素的加入破坏了醋酸纤维素的结晶度,但纤维内部仍具有明显的核壳结构。此外,醋酸纤维素与农药阿维菌素之间是物理作用,复合后并不影响药效的发挥。最后,对不同浓度阿维菌素从核壳纤维中的释放行为进行了研究,结果显示了三阶段的释放行为,即延迟释放、均匀释放和缓慢释放,这一释放行为为阿维菌素的有效利用提供了保障。

The purpose was to obtain slow release fibers with the advantages of less toxicity,less pollution,high efficacy and less residue.Firstly,cellulose acetate as drug delivery carrier,avermectin as released pesticide,the drug-loaded fibers with core-shell structure were made through coaxial electrospinning technology,and characterized their structure and morphology.The results showed that the fibers had obvious core-shell structure,although the addition of avermectin damaged the crystallinity of cellulose acetate.Moreover,physical action between cellulose acetate and avermectin did not affect the efficiency of pesticide.Finally,The release behavior of avermectin with different concentrations from core-shell fibers was further investigated.There were three distinct releasing stages in the whole process,namely,delayed-release,uniformly slow-release and rather slow-release,which were beneficial for effectively releasing avermectin.