慢性荨麻疹患者血清中D-二聚体水平和IL-33表达及意义

Serum D-dimer and IL-33 in patients with chronic urticaria

目的:探讨慢性荨麻疹(CU)患者血清中D-二聚体水平和IL-33的水平及其临床意义。方法:将63例CU患者依据自身血清皮肤试验(ASST)结果进行分组,取同期体检健康者作为对照组,采用ELISA法检测三组患者血清中D-二聚体水平和IL-33水平并进行比较。结果:63例CU患者中,37例ASST阳性(58.73%),26例阴性(41.27%)。相比对照组D-二聚体水平2.437±0.120)mg/L],ASST(+)组(25.797±7.756)mg/L]和ASST(-)组(30.605±9.101)mg/L]均明显增加(t值分别为10.25、10.58,P值均<0.05),但ASST(-)组与ASST(+)组两组间无明显差异(t=1.39,P>0.05)。ASST(+)组血清中IL-33含量(0.237±0.037)pg/mL]明显高于对照组(0.069±0.001)pg/mL],t=7.78,P<0.05,而ASST(-)组IL-33水平(0.112±0.028)pg/mL]无明显变化(t=2.63,P>0.05),ASST(-)和ASST(+)间有明显差异(t=4.69,P<0.05)。结论:CU患者血清中D-二聚体水平及ASST(+)组IL-33水平升高,可能导致机体免疫系统失衡,在CU的发生与发展中发挥一定作用。

Objective:To explore the levels and clinical characteristics of serum D-dimer and IL-33 in patients with chronic urticaria.Methods:A total of 63 patients with chronic urticarial were divided into a positive group and a negative group according to the results of the autologous serum skin test,in addition,a normal control group was set.The levels of serum D-dimer and IL-33 were measured by ELISA in all three groups.Results:Of the 63 patients with chronic urticaria,37 were positive for ASST,26 were negative for ASST.Serum levels of D-dimer and IL-33 in patients with chronic urticaria of the positive group were significantly higher than that in normal controls(all P<0.05).There was no significant difference in D-dimer level between the positive group and negative group(P>0.05).Conclusion:The levels of D-dimer are high in patients with chronic urticaria,the levels of IL-33 are high in positive group,and these elevated D-dimer and IL-33 may lead to the imbalance of the immune system and increase the occurrence and development of chronic urticaria.